Results 91 to 100 of about 41,917 (266)
Structural Insights into Dynamin-Mediated Membrane Fission
, 2012 Dynamin is a multidomain mechanochemical guanine triphosphatase that catalyzes membrane scission, most notably of clathrin-coated endocytic vesicles. A number of recent publications have provided structural and mechanistic insights into the formation of ...
Held, M. +13 more
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Synaptic Vesicle Dynamics sans Dynamin [PDF]
, 2007 The neuron-specific guanosine triphosphatase dynamin 1 has been hypothesized to be critically required for pinching off synaptic vesicles during endocytosis. In a recent publication in Science, Ferguson et al.
Klingauf, Jurgen, Klingauf, J.
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α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling
Frontiers in Cellular Neuroscience, 2017 α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In Parkinson’s disease (PD) and several other neurodegenerative disorders, aberrant oligomerization and aggregation of α-synuclein lead to synaptic dysfunction and ...
Audrey T. Medeiros +4 more
doaj +1 more source
BMEMat, EarlyView.MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen +10 more
wiley +1 more source
Dynamin-mediated membrane fission
, 2012 Membrane fission is required for vesicular traffic between intracellular compartments. Dynamin is a GTPase implicated in vesicle scission during Clathrin-mediated endocytosis. It polymerizes into a helix at the neck of endocytic buds. Upon GTP hydrolysis,
Morlot, Sandrine
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Dynamin Functions and Ligands: Classical Mechanisms Behind [PDF]
, 2020 Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane.
Mahaveer Singh +2 more
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Dynamin-2 nervous system disorders [PDF]
, 2014 Artículo de publicación ISIDynamin-2 is a pleiotropic GTPase whose best-known function is related to membrane scission during vesicle budding from the plasma or Golgi membranes.
Momboisse, Fanny +8 more
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Interdisciplinary Medicine, EarlyView.This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma +6 more
wiley +1 more source
Dynamin: Possible Mechanism of “Pinchase” Action
, 1999 Dynamin is a GTPase playing an essential role in ubiquitous intra cellular processes involving separation of vesicles from plasma membranes and membranes of cellular compartments. Recent experimental progress (Sweitzer and Hinshaw, 1998. Cell.
Kozlov, Michael M.
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A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source