Results 81 to 90 of about 41,917 (266)
Frontiers in Cellular Neuroscience, 2016 Under basal conditions the action potential firing rate of adrenal chromaffin cells is lower than 0.5 Hz. The maintenance of the secretory response at such frequencies requires a continuous replenishment of releasable vesicles.
José Moya-Díaz +7 more
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Dynamin and receptor‐mediated endocytosis [PDF]
FEBS Letters, 1996 The internalization of receptor‐bound ligands involves concentration of cell surface receptors in specialized areas of the plasma membrane and subsequent formation of clathrin‐coated vesicles. The complex process of invagination, constriction and budding of clathrin‐coated vesicles employs the coordinated actions of several proteins.
openaire +2 more sources
Advanced Intelligent Systems, EarlyView.Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson +8 more
wiley +1 more source
The role of scaffold reshaping and disassembly in dynamin driven membrane fission
eLife, 2018 The large GTPase dynamin catalyzes membrane fission in eukaryotic cells, but despite three decades of experimental work, competing and partially conflicting models persist regarding some of its most basic actions.
Martina Pannuzzo +2 more
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT DNM1 encephalopathy is a rare autosomal dominant genetic condition characterized by a range of neurological and developmental manifestations. The typical phenotype is severe, including profound intellectual disability, treatment‐resistant epilepsy, ataxia, and structural brain abnormalities. However, milder presentations have increasingly been
Caroline Crain +6 more
wiley +1 more source
Dynamic Remodeling of Membranes Catalyzed by Dynamin
, 2011 This chapter discusses the dynamic remodeling of membranes catalyzed by dynamin. Members of the dynamin family of large GTPases are unique among proteins involved in remodeling cell membranes.
Pucadyil, Thomas J., Thomas J. Pucadyil
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The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases
Membranes, 2012 Eukaryotic cells have complicated membrane systems. The outermost plasma membrane contains various substructures, such as invaginations and protrusions, which are involved in endocytosis and cell migration.
Fatemeh Safari, Shiro Suetsugu
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Cell division screens and dynamin [PDF]
Biochemical Society Transactions, 2008 Cell division is the most fundamental process in the development of all living organisms. The generation of cell diversity throughout development, the multiplication of cells during wound repair and the maintenance of stem cells in several tissues and organs all rely on proper progress through cell division.
Mary Kate, Bonner, Ahna R, Skop
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A role for amphiphysin in AP-1/clathrin coat formation [PDF]
, 2013 Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. Clathrin, in combination with different adaptor proteins, is the major coat protein for vesicle formation at the plasma membrane, endosomes, and the ...
Huser Studer, Sonja
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BMEMat, EarlyView.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source