Results 141 to 150 of about 37,365 (212)

Lipid packing contributes to the confinement of caveolae to the plasma membrane. [PDF]

Elife
Larsson E, Kabedev A, Pace H, Lindwall J, Bano F, Rae J, Parton RG, Bergström CA, Parmryd I, Bally M, Lundmark R.   +10 more
europepmc   +1 more source

Rev‐erb‐α in Skeletal Muscle Adaptation: Integrating Circadian Control Mechanisms and Exercise Dynamic Responses

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Circadian rhythms orchestrate a host of biological processes in a time‐dependent manner to maintain homeostasis in response to exercise. Within this framework, Rev‐erb‐α, an intracellular nuclear receptor and transcriptional regulator, transcends its role in circadian rhythms to drive myogenesis, muscle remodeling, primary metabolism, and ...
Ivo Vieira de Sousa Neto, Alisson Luiz da Rocha, Ana Paula Pinto, Eliézer Lucas Pires Ramos, Eduardo Rochete Ropelle, José Rodrigo Pauli, Ellen Cristini de Freitas, Adelino Sanchez Ramos da Silva   +7 more
wiley   +1 more source

Plant organelle division orchestrated by the mosaic machinery of endosymbiotic relics and eukaryotic host factors. [PDF]

Plant Physiol
Lee J, Weerasooriya H, Chen C, Hu J.
europepmc   +1 more source

Electrical Pulse Stimulation Partially Restores Insulin Signaling in Palmitate‐Induced Insulin‐Resistant Skeletal Muscle Cells via Mitochondrial Remodeling and Contractile Activity‐Dependent Secretome

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Lipid oversupply induces insulin resistance in skeletal muscle (SkM), partly by altering mitochondrial function and dynamics. Although electrical pulse stimulation (EPS) improves insulin signaling in myotubes, the mechanisms contributing to this effect under lipotoxic conditions remain unclear.
Alessandro Falcone, Sevgican Yilmaz, Mona Hendlinger, Patrick Schrauwen, Polina Lipaeva, Marlene Piribauer, Geronimo Heilmann, Sandra Trenkamp, Michael Roden, Lucia Mastrototaro   +9 more
wiley   +1 more source

PACSIN2 regulates mercaptopurine cytotoxicity and cellular biomechanics through Rac1 modulation in intestinal epithelial cells. [PDF]

Front Pharmacol
Norbedo A, Zudeh G, Fiducioso D, Senigagliesi B, Parisse P, Casalis L, Decorti G, Lucafò M, Stocco G.   +8 more
europepmc   +1 more source

Chemotherapy‐Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle‐Brain Mechanistic Framework With Implications for Exercise Oncology

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Chemotherapy commonly induces skeletal muscle dysfunction and cognitive impairment, complications that reduce treatment tolerance and quality of life. Skeletal muscle mass frequently declines during chemotherapy, with cohort studies reporting losses of 3%–10% across treatment courses, while chemotherapy‐induced cognitive impairment affects up ...
SoYoung Ahn, Jin‐Soo Kim, Daniel A. Galvao, Dennis R. Taaffe, Dong Hyun Yoon, Carolyn McIntyre, Christelle Schofield, Yoon Jung Chang, Jihee Min, Wook Song, Robert U. Newton   +10 more
wiley   +1 more source

PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress. [PDF]

Acta Pharmacol Sin
Wang CM, Li Y, Yi YH, Chen X, Lan T, Lou HY, Jian WC, Wang MJ, Yu SY.   +8 more
europepmc   +1 more source

Shear Stress‐Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
The vasculo‐splenic axis during exercise: shear stress triggers the release of medium/large extracellular vesicles from vascular endothelial cells via activation of Piezo1, shuttling Piezo1 to the smooth muscle cells in the splenic capsule; the translocated Piezo1 within the splenic capsule acts as a downstream effector of the α1‐adrenergic receptor ...
Jing Lou, Mingzong Yang, Yang Hu, Xuyun Liu, Han Li, Zihang Feng, Yuxin Xi, Changyang Xing, Lijun Yuan, Jia Li, Shengpeng Wang, Feng Gao, Xing Zhang   +12 more
wiley   +1 more source

A local solution to local load: Myo1E as a tension-responsive actuator in clathrin-mediated endocytosis. [PDF]

Proc Natl Acad Sci U S A
Xu M, Ostap EM.
europepmc   +1 more source

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source