Role of the Host Membrane Trafficking Protein Dynamin 2 in Cell-to-Cell Spread of Bacterial Pathogens. [PDF]
Ireton K.
europepmc +1 more source
Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis
Objective The relationship between age at menopause and osteoarthritis (OA) remains unclear. Methods The genetic commonalities between age at menopause and OA were investigated using data from publicly accessible genome‐wide association studies. A variety of methods were employed in this exploration, such as linkage disequilibrium score regression ...
Bingru Luo +3 more
wiley +1 more source
Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release. [PDF]
Emperador-Melero J +4 more
europepmc +1 more source
ABSTRACT Small extracellular vesicles (EVs) from bovine milk and whey are emerging as biologically active carriers of microRNA (miRNA), yet their composition and variability among different dairy sources remain incompletely understood. We conducted an integrated characterisation of EV‐associated miRNAs isolated from milk and whey collected from three ...
Caterina Trevisan +3 more
wiley +1 more source
Dynamic regulation of TASK-1 channels under cellular stress. [PDF]
Yu Y, Curry J, Tankersley S, Hu K.
europepmc +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Axonal regeneration and hyperglycemia in wound healing: a review on the role of activin A, TNFRSF10B, and Synaptophysin. [PDF]
Patel J, Rai V.
europepmc +1 more source
Formulation of Peptide‐Based Nanoparticles Using a Microfluidic Device
A case study using the TAMARA microfluidic device (Inside Therapeutics) was performed for peptide‐based nanoparticles under different operational parameters such as mixing channel geometry, total flow rate, and flow rate ratio. In this context, WRAP5 cell‐penetrating peptide‐based nanoparticles for siRNA or pDNA delivery demonstrated enhanced ...
Thania Hammoum +6 more
wiley +1 more source
An allosteric network within dynamin
Dynamins are large enzymes that catalyse the hydrolysis of GTP (GTPase activity). They assemble through oligomerisation into helical polymers during endocytosis to facilitate membrane scission and vesicle release in all known eukaryotic cell types ...
Collett, Michael
core
Dynamin 2 Regulates Mitochondrial Mitotic Fission in Pulmonary Hypertension. [PDF]
Dasgupta A +18 more
europepmc +1 more source

