Results 171 to 180 of about 37,365 (212)

Iron Homeostasis and Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Peng Yang, Zhitian Shi, Qin Huang, Zhihong Tu, Yue Sun, Lin Wang, Yonglong Wei   +6 more
wiley   +1 more source

Disrupted Mitochondrial Quality Control in Atherosclerotic Disease: Mitophagy and Dynamics in Focus. [PDF]

JACC Basic Transl Sci
Wilcox T, Hansen J, Blanker A, Widlansky ME.   +3 more
europepmc   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1708-1725, October 2026.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan, Shuang Sui, Zhenghua Yang, Kaiwen Zhang, Qiang Hu   +4 more
wiley   +1 more source

Synaptic Proteostasis in Health and Disease

Journal of Neurochemistry, Volume 170, Issue 10, October 2026.
The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley   +1 more source

Bovine coronavirus enters PBIECs via membrane fusion and clathrin-, caveolin-mediated endocytosis, macropinocytosis. [PDF]

Virulence
Chen C, Su N, Zhao L, Li N, Ma Z, Luo B, Liu W, Song B, Zhang L, Guo K.   +9 more
europepmc   +1 more source

Identification and Validation of Biomarkers Associated With Mitochondrial Dynamics in Preeclampsia

Journal of Obstetrics and Gynaecology Research, Volume 52, Issue 10, October 2026.
ABSTRACT Aim Despite studies highlighting mitochondrial dynamics in preeclampsia (PE), the regulatory mechanisms of mitochondrial dynamics‐related genes (MD‐RGs) in PE remain unclear. This study aims to explore these mechanisms. Methods PE‐related datasets (GSE10588 and GSE98224) and 23 MD‐RGs were used.
Xueying Liu, Mei Liu, Chuanyan Chen, Xiaoyan Gao, Zhenru Xu, Wenxiao Gao, Haining Qi, Qi Li, Jianhong Xing   +8 more
wiley   +1 more source

Ligand-Baited Proteomics Reveals Vesicle Trafficking Proteins as Putative Site of Action of Indaziflam. [PDF]

J Agric Food Chem
Mahey M, Lundquist PK, Patterson EL.
europepmc   +1 more source

Identification of Critical Amino Acid Residues Required for the Polar Localization of a Rice Manganese Transporter

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5340-5351, October 2026.
ABSTRACT Rice has developed an efficient system for manganese (Mn) uptake, mediated by two distinct transporters, OsNramp5 and OsMTP9. These transporters exhibit polar localization at the root exodermis and endodermis; however, the mechanisms underlying their polar localization and their role in Mn uptake remain unclear.
Noriyuki Konishi, Jian Feng Ma
wiley   +1 more source

Solving the mechanism of Notch activation: a geneticist's perspective. [PDF]

Genetics
Greenwald I.
europepmc   +1 more source

Effects of exercise in a fed or fasted state on mitochondrial dynamics regulators in the skeletal muscle of recreationally active males

Experimental Physiology, Volume 111, Issue 10, Page 4525-4540, 1 October 2026.
Abstract Exercise and nutritional modulation favourably alter mitochondrial quantity and quality in skeletal muscle. Mitochondrial dynamics, the coordination of fission and fusion events, are poised to mediate key aspects of organelle adaptation that arise from exercise.
Elya J. Ritenis, Christos G. Stathis, Matthew B. Cooke, Stephen Keenan, Andrew Philp, Donny M. Camera   +5 more
wiley   +1 more source