Results 171 to 180 of about 41,917 (266)

Whole Blood Transcriptomic Response to Perioperative Dexamethasone in Total Knee Arthroplasty: A Targeted Panel Analysis

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Changes in the transcriptome of immune cells are predictive of clinical outcomes. These effects may be surgery‐specific and possibly modulated by glucocorticoids. We investigated the immune response and the impact of dexamethasone on the response in patients undergoing total knee arthroplasty (TKA). Methods The transcript levels (n =
Asger Krog Mølgaard, Kasper Smidt Gasbjerg, Lukas Balsevicius, Britt Cappelen, Adile Orhan, Helin Yikilmaz Pardes, Ole Mathiesen, Thomas Litman, Daniel Hägi‐Pedersen, Ismail Gögenur   +9 more
wiley   +1 more source

Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD. [PDF]

Probl Endokrinol (Mosk)
Akl MM, Ahmed A.
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Decapod iridescent virus 1 (DIV1) enters hematopoietic <i>Cherax quadricarinatus</i> cells via caveola-mediated endocytosis in a pH-dependent manner. [PDF]

J Virol
Zheng Q, Chen X, Zhao F, Zhang J, Chen J.   +4 more
europepmc   +1 more source

The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Drug uptake is constrained by epithelial barriers, such as the intestine and the blood–brain barrier, which express efflux pumps such as the ABC‐transporter ABCB1. Therefore, drugs targeting the central nervous system frequently require co‐administration of efflux inhibitors to facilitate sufficient target engagement. Conversely, certain drugs designed
Nadja Hellmann, Christian Kersten, Thomas Efferth, Dirk Schneider   +3 more
wiley   +1 more source

DNM2 lipid binding drives centronuclear myopathy and represents a potential therapeutic target. [PDF]

JCI Insight
Gómez-Oca R, Massana-Muñoz X, Reiss D, De Carvalho Neves J, Diedhiou N, Silva-Rojas R, Cowling BS, Goret M, Laporte J.   +8 more
europepmc   +1 more source

Identification of Oncolytic Avian Reovirus Receptors in B16-F10 Cells and the Signaling-Mediated Pathways Involved in Viral Entry. [PDF]

Viruses
Hsu CY, Tu BY, Li JY, Liao TL, Wu YY, Lin CY, Chang YK, Munir M, Munir M, Liu HJ.   +9 more
europepmc   +1 more source

Membrane Constriction by Dynamin through GTP-Driven Conformational Changes from Coarse-Grained Molecular Dynamics Simulations. [PDF]

J Phys Chem Lett
Mahmood MI, Kubo S, Noguchi H, Okazaki KI.   +3 more
europepmc   +1 more source

The dynamin-related protein <i>Osdrp1c</i> plays an essential role in rice root elongation (<i>Oryza sativa</i> L.). [PDF]

Front Plant Sci
Hua Y, Guo Z, Jia L, Mu W, Li X, Li Q, Ma T, Chen Y, Qiu S, Zhang W, Ding W.   +10 more
europepmc   +1 more source

Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects. [PDF]

RSC Med Chem
Zhang C, Guo J, Liu Z, Huang X, Dong S, Hu C, Xiao J.   +6 more
europepmc   +1 more source