Results 121 to 130 of about 50,252 (279)

The Arabidopsis peroxisome division mutantpdd2is defective in theDYNAMIN-RELATED PROTEIN3A(DRP3A) gene [PDF]

Plant Signaling & Behavior, 2009
In plants, the division of peroxisomes is mediated by several classes of proteins, including PEROXIN11 (PEX11), FISSION1 (FIS1), and DYNAMIN-RELATED PROTEIN3 (DRP3). DRP3A and DRP3B are two homologous dynamin-related proteins playing overlapping roles in the division of both peroxisomes and mitochondria, with DRP3A performing a stronger function than ...
Kyaw, Aung, Jianping, Hu
openaire   +2 more sources

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source

Impact of Drp1 Loss on Organelle Interaction, Metabolism, and Inflammation in Mouse Liver

Cells
Dynamin-related protein 1 (Drp1) is a crucial player in mitochondrial fission and liver function. The interactions between mitochondria, endoplasmic reticulum (ER), and lipid droplets (LDs) are fundamental for lipid metabolism.
Lixiang Wang, Seiji Nomura, Nao Hasuzawa, Sadaki Yokota, Ayako Nagayama, Kenji Ashida, Junjiro Rikitake, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +9 more
doaj   +1 more source

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis [PDF]

, 2014
In human cells, the RIPK1-RIPK3-MLKL-PGAM5-Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence
Baekelandt, V, Bertrand, Mathieu, Bruggeman, Inge, Dondelinger, Yves, Gonçalves, Amanda, Goossens, Vera, Grootjans, Sasker, Remijsen, Quinten, Roelandt, Ria, Takahashi, Nozomi, Van den Haute, C, Vanden Berghe, Tom, Vandenabeele, Peter, Vanlangenakker, Nele   +13 more
core   +3 more sources

The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. [PDF]

RSC Med Chem, 2023
Odell LR, Jones NC, Chau N, Robertson MJ, Ambrus JI, Deane FM, Young KA, Whiting A, Xue J, Prichard K, Daniel JA, Gorgani NN, O'Brien TJ, Robinson PJ, McCluskey A.   +14 more
europepmc   +1 more source

TheArabidopsisDynamin-Related Protein2 Family Is Essential for Gametophyte Development  

The Plant Cell, 2010
AbstractClathrin-mediated membrane trafficking is critical for multiple stages of plant growth and development. One key component of clathrin-mediated trafficking in animals is dynamin, a polymerizing GTPase that plays both regulatory and mechanical roles.
Steven K, Backues, David A, Korasick, Antje, Heese, Sebastian Y, Bednarek   +3 more
openaire   +3 more sources

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion [PDF]

, 2006
Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact ...
Chan, David C., Griffin, Erik E.
core   +3 more sources

Force stimulation promotes nerve regeneration by restoring cellular energy

BMEMat, EarlyView.
Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang, Chen Cai, Hetao Xie, Yupeng Yang, Lei Li, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Meiwan Chen, Yuanhua Sang, Bing Ji, Zenan Wang   +10 more
wiley   +1 more source

Microbe-Derived Extracellular Vesicles as Carriers for Doxorubicin Delivery to Colorectal Cancer Cells

Pharmaceuticals
Background/Objectives: Microbe-derived extracellular vesicles (MEVs) provide a biocompatible, naturally derived platform for drug delivery. Methods: We encapsulated doxorubicin in Lactobacillus plantarum-derived EVs and evaluated their ability at ...
Sujin Lee, Dagyeong Guk, Youngdo Jeong, Hansol Kim, Min Chul Park, Seong-Bo Kim, Sung Tae Kim   +6 more
doaj   +1 more source