Results 131 to 140 of about 28,974 (239)

Functional Specialization of Clathrin‐Independent Endocytic Routes: Mechanisms and Cellular Roles

Traffic, Volume 27, Issue 3, September 2026.
Distinct clathrin‐independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com. ABSTRACT Clathrin‐independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin‐mediated endocytosis.
Andrea Francesco Benvenuto, Amir Fardin, Matteo Balestra, Pier Paolo Di Fiore, Chiara Tordonato, Sara Sigismund   +5 more
wiley   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, Volume 13, Issue 45, 13 August 2026.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release. [PDF]

Elife
Emperador-Melero J, Del Signore SJ, De León González KM, Kaeser PS, Rodal AA.   +4 more
europepmc   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, Volume 13, Issue 45, 13 August 2026.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Dynamin 2 Regulates Mitochondrial Mitotic Fission in Pulmonary Hypertension. [PDF]

Circ Res
Dasgupta A, Chen KH, Wu D, Yerramilli VS, Lima PDA, Martin AY, Bentley RET, Ott BP, Nandani T, Mewburn JD, Tian L, Al-Qazazi R, Emon IM, Colpman P, Jefferson L, Noordhof C, Jones O, Hindmarch CCT, Archer SL.   +18 more
europepmc   +1 more source

Flower Delivery: The Emergence of FLOWER (FWE) as a Multifunctional Regulator of Endo‐Lysosome‐Related Organelle Trafficking Across Cell Types

BioEssays, Volume 48, Issue 8, August 2026.
FLOWER (FWE) is a small alternatively spliced transmembrane protein whose conserved four‐transmembrane topology enables interaction with trafficking machinery and membrane phospholipids. Initially characterized by synaptic vesicle endocytosis, FWE is now recognized as a critical mediator of endo‐lysosome related organelle trafficking across diverse ...
Justin C. Rudd, Laura A. Hansen
wiley   +1 more source

Dynamins maintain nuclear envelope homeostasis and genome stability. [PDF]

Nat Commun
Aveleira C, Martial T, Carrique L, Gaspar R, Caulino-Rocha A, Myatt I, Wendler F, Lascaux P, Le Claire M, Bancroft J, Smythe C, Ramadan K, Raimundo N, Milosevic I.   +13 more
europepmc   +1 more source

The Zuo Jin Wan Formula Reverses Cisplatin Resistance in Gastric Cancer by Inhibiting the Mitochondrial Translocation of Dynamin‐Related Protein 1 and Its Mediated Mitochondrial Fission and Mitophagy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Gastric cancer is a major global health concern characterized by high incidence and mortality rates. One of the key challenges in treating gastric cancer is the development of resistance to chemotherapy drugs like cisplatin (DDP). This study aimed to investigate the efficacy of Zuo Jin Wan (ZJW), a traditional Chinese medicine, in ...
Zhuo Zhao, Meijie Yuan, Xiao Yang, Qing Ji, Guobin Liu, Qingfeng Tang, Jian Sun   +6 more
wiley   +1 more source

β‐Elemene Triggers Drp1‐Dependent Mitochondrial Fission Through CDK1/Cyclin B1 Signaling in Cervical Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This study reveals a novel molecular mechanism by which the natural sesquiterpene β‐Elemene exerts anti‐tumor effects in cervical cancer. β‐Elemene treatment promotes the activation of the CDK1/Cyclin B1 kinase complex. Activated CDK1/Cyclin B1, in turn, phosphorylates the mitochondrial fission protein Drp1 at serine 616.
Zhifang Li, Ling Tang, Mingyan Wang, Qiong Yu, Chen Chen, Jiyi Xia, Xiaolan Yu   +6 more
wiley   +1 more source

The dynamin-related protein <i>Osdrp1c</i> plays an essential role in rice root elongation (<i>Oryza sativa</i> L.). [PDF]

Front Plant Sci
Hua Y, Guo Z, Jia L, Mu W, Li X, Li Q, Ma T, Chen Y, Qiu S, Zhang W, Ding W.   +10 more
europepmc   +1 more source