Results 191 to 200 of about 28,974 (239)

Traumatic Brain Injury and Endocytosis: Reduced Rodent Hippocampal Endocytosis Proteins and Human Clathrin Light Chain Polymorphisms Are Associated with Impaired Neurological Outcomes After TBI. [PDF]

Mol Neurobiol
Svirsky SE, Roberts A, Parry M, Henchir J, Dixon CE, Jackson TC, Chang Y, Conley Y, Puccio AM, Carlson SW.   +9 more
europepmc   +1 more source

Dynamin 1 promotes colorectal cancer progression by activating the PI3K/Akt signaling pathway. [PDF]

J Transl Med
Chen R, Hong R, Chen L, Liu Q, Cao Z, Wang H, Han S, Ke C.   +7 more
europepmc   +1 more source

Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability. [PDF]

J Am Chem Soc
Alimohamadi H, Luo EW, Liu X, Iqbal W, Yang R, Gupta S, Nolden KA, Mandal T, Hill RB, Duan L, Wong GCL.   +10 more
europepmc   +1 more source

Dynamin-Related Protein 1-Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light-Induced Epithelial-Mesenchymal Transition in Retinal Aging. [PDF]

Aging Cell
Li ZY, Yang D, Huang Y, Li Y, Zhao T, Xu Y.   +5 more
europepmc   +1 more source

Roles in physiology and disease of the inositol phosphatase synaptojanin 1. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids
De Camilli P.
europepmc   +1 more source

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Genetic Studies on Dynamin Function inDrosophila

Journal of Neurogenetics, 1993
The shibire(ts2) mutation of Drosophila melanogaster causes a temperature sensitive inhibition of endocytosis; this in turn leads to synaptic-vesicle depletion and consequent paralysis. Heat-pulses delivered during development of shibire(ts2) individuals affect the morphology of a number of adult structures. A simple screening protocol has been used to
M, Ramaswami, S, Rao, A, van der Bliek, R B, Kelly, K S, Krishnan   +4 more
openaire   +2 more sources

Phosphorylation of dynamin I and synaptic-vesicle recycling

Trends in Neurosciences, 1994
In nerve terminals, neurotransmitters are packaged in synaptic vesicles, and released by exocytosis. Empty synaptic vesicles are rapidly recycled for reuse by endocytosis. Much progress has been made in identifying the proteins involved in synaptic-vesicle trafficking, but the mechanism and regulation of endocytosis have largely remained an enigma. One
P J, Robinson, J P, Liu, K A, Powell, E M, Fykse, T C, Südhof   +4 more
openaire   +2 more sources

Iminochromene Inhibitors of Dynamins I and II GTPase Activity and Endocytosis

Journal of Medicinal Chemistry, 2010
Herein we report the synthesis of discrete iminochromene ("iminodyn") libraries (14-38) as potential inhibitors of dynamin GTPase. Thirteen iminodyns were active (IC(50) values of 260 nM to 100 microM), with N,N-(ethane-1,2-diyl)bis(7,8-dihydroxy-2-iminochromene-3-carboxamide) (17), N,N-(ethane-1,2-diyl)bis(7,8-dihydroxy-2-iminochromene-3-carboxamide) (
Hill, Timothy A., Mariana, Anna, McCluskey, Adam, Gordon, Christopher P., Odell, Luke R., Robertson, Mark J., McGeachie, Andrew B., Chau, Ngoc, Daniel, James A., Gorgani, Nick N., Robinson, Phillip J.   +10 more
openaire   +5 more sources

Calcium Binds Dynamin I and Inhibits Its GTPase Activity

Journal of Neurochemistry, 1996
Abstract: Synaptic vesicle recycling is a neuronal specialization of endocytosis that requires the GTPase activity of dynamin I and is triggered by membrane depolarization and Ca2+ entry. To establish the relationship between dynamin I GTPase activity and Ca2+, we used purified dynamin I and analyzed its interaction with Ca2+ in vitro.
J P, Liu, Q X, Zhang, G, Baldwin, P J, Robinson   +3 more
openaire   +2 more sources