Results 191 to 200 of about 50,252 (279)

APOE4 Drives Sex‐ and Diet‐Dependent Effects on AD‐Like Pathology, Cognition, and Mitochondrial Function

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
APOE4 interacts with sex and diet to influence brain mitochondrial function. ABSTRACT Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele promotes disease. While factors like diet and sex may modify AD susceptibility in APOE4 carriers, the interaction between these factors is ...
Chelsea N. Johnson, Colton R. Lysaker, Xin Cao, Vivien Csikos, Frederick Boakye, Paul J. Kueck, Edziu Franczak, Paige C. Geiger, Jill K. Morris, John P. Thyfault, Heather M. Wilkins   +10 more
wiley   +1 more source

Kenny is the adaptor protein for ubiquitin-dependent mitophagy in <i>Drosophila melanogaster</i>. [PDF]

Autophagy Rep
Osei Acheampong H, Insolera R.
europepmc   +1 more source

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Aging Cell, Volume 25, Issue 5, May 2026.
Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu, Gang Ning, Mintao Jian, Ajian Peng, Haoyu Wang, Bonan Li, Xing Zhou   +6 more
wiley   +1 more source

BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes. [PDF]

Am J Physiol Cell Physiol
Rodwell-Bullock J, Blau E, Ganguly A, Deaton C, Johnson GVW.   +4 more
europepmc   +1 more source

Preoperative Beta‐Hydroxy‐Beta‐Methyl‐Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim The liver exhibits a remarkable regenerative capacity, enabling this organ to maintain homeostasis even after significant injury. However, hepatic regeneration requires sufficient energy to sustain cellular hypertrophy and proliferation, thus ensuring efficient tissue repair.
A. L. Vieira‐da‐Silva, M. V. Esteca, F. A. Silva, I. A. Divino, F. S. Carneiro, E. R. Ropelle, A. S. Torsoni, I. L. Baptista   +7 more
wiley   +1 more source

1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis. [PDF]

Nat Commun
Liao W, Cao D, Wang Y, Du Z, Yao J, Dou P, Zheng Y, Wang Z, Chen X, Wang P, Ma C, Chen H, Diao X, Wang K, Ding K.   +14 more
europepmc   +1 more source

The regulation of dynamin I interactions in synaptic vesicle endocytosis

, 2006
Synaptic vesicle endocytosis is essential for the maintenance of synaptic transmission. The process involves a cascade of protein-protein interactions involving many proteins, the majority of which are essential. This pathway was investigated by perturbation of protein-protein interactions using the penetratin vector system.
openaire   +1 more source

Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

Cell Proliferation, Volume 59, Issue 5, May 2026.
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li, Ziwei Yan, Yueming Dai, Hanjia Cai, Yue Chen, Yuyi Chen, Ruofan Jin, Wen Sun, Hua Wang   +8 more
wiley   +1 more source

Binding of Bacillus subtilis dynamin-like protein DynA to the bacterial membrane is essential for effective phage defense. [PDF]

FEBS J
Shafqat S, Repnik U, Bramkamp M.
europepmc   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source