Results 201 to 210 of about 50,252 (279)

Friction-driven scission: How nonlocal mechanisms contribute to membrane fission across domains of life. [PDF]

Sci Adv
Landajuela A, Gomis Perez C, Bassereau P, Callan-Jones A, Karatekin E.   +4 more
europepmc   +1 more source

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3788-3806, May 2026.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

A phosphoinositide switch from PI(4,5)P₂ to PI4P triggers endocytosis by inducing dynamin-mediated fission in secretory cells. [PDF]

Sci Adv
Guo X, Wei L, Kundu N, Shin W, Chan CY, Han S, Mohseni A, Molakarimi M, Sun M, Wu XS, Jin Y, Hinshaw JE, Wu LG.   +12 more
europepmc   +1 more source

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

Combinatorial treatment with donafenib and quercetin suppresses lipid metabolism in HepG2 cells by targeting the CREB1/DRP1/SREBP1 axis. [PDF]

Transl Cancer Res
Xiang L, Shi J, Huang X, Zhou S.
europepmc   +1 more source

Skeletal muscle mitochondrial marker responses to a single bout and 6 weeks of high load versus high volume resistance training in previously trained men

Experimental Physiology, Volume 111, Issue 5, Page 2564-2574, 1 May 2026.
Abstract The effects of high‐load (HL) versus high‐volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this study was to interrogate mitochondrial mRNA and protein responses to acute and chronic HL versus HV RT.
Breanna Mueller, Carlton D. Fox, Hailey A. Parry, Paulo H. C. Mesquita, Christopher G. Vann, Bradley A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason M. McIntosh, Darren T. Beck, Kaelin C. Young, Stuart M. Phillips, Andreas N. Kavazis, Michael D. Roberts   +13 more
wiley   +1 more source

Chasteberry extract alleviates rotenone-triggered testicular injury in rats by modulating oxidative stress, inflammation, apoptosis, and mitochondrial dysfunction. [PDF]

Sci Rep
Saad HM, Ashoura NR, Salama AR, Wasef LG, Elrehim AMA, Essa BH, Saleh NA, Elsawasany A, Awad AA.   +8 more
europepmc   +1 more source

Roles of DRP1 and the fission protein interactome as regulators of cellular stability and sarcopenia in skeletal muscle aging. [PDF]

Aging Adv
Nivedya C, Venkhatesh P, Rodriguez BI, Le H, Afolabi J, Marshall A, Neikirk K, Masenga SK, Aftab M, Kazma LJ, Katti P, Hinton A.   +11 more
europepmc   +1 more source

DYN-1 regulates SPD-2 and PLK-1 localization and mitotic spindle pole organization. [PDF]

Mol Biol Cell
Dierlam C, Held S, Hastings J, Anyanwu L, Newman RH, Iyer J.   +5 more
europepmc   +1 more source

From molecular mechanisms of glycosphingolipid function to bio-therapeutic applications. [PDF]

Cell Mol Life Sci
Saha A, Johannes L.
europepmc   +1 more source