Results 31 to 40 of about 28,974 (239)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Defects in expression of genes related to synaptic vesicle traffickingin frontal cortex of Alzheimer’s disease

Neurobiology of Disease, 2003
Loss of synapses correlates with cognitive decline in Alzheimer’s disease (AD). However, molecular mechanisms underlying the synaptic dysfunction and loss are not well understood.
Pamela J Yao, Min Zhu, Eunice I Pyun, Andrew I Brooks, Stavros Therianos, Victoria E Meyers, Paul D Coleman   +6 more
doaj   +1 more source

Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion

Biology Open, 2014
Dynamins are GTPases that are required for separation of vesicles from the plasma membrane and thus are key regulators of endocytosis in eukaryotic cells. This role for dynamin proteins is especially crucial for the proper function of neurons, where they
Jared A. Talbot, Ko W. Currie, Bret J. Pearson, Eva-Maria S. Collins   +3 more
doaj   +1 more source

Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin

BMC Cell Biology, 2011
Background The amyloid precursor protein (APP) is cleaved by β- and γ-secretases to generate toxic amyloid β (Aβ) peptides. Alternatively, α-secretases cleave APP within the Aβ domain, precluding Aβ formation and releasing the soluble ectodomain, sAPPα ...
Slack Barbara E, Blusztajn Jan K, Carey Robyn M   +2 more
doaj   +1 more source

Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. [PDF]

PLoS ONE, 2013
Isoaspartate (isoAsp) formation is a major source of protein damage that is kept in check by the repair function of protein L-isoaspartyl methyltransferase (PIMT).
Zhenxia Qin, Rachel S Kaufman, Rana N Khoury, Mitri K Khoury, Dana W Aswad   +4 more
doaj   +1 more source

Entacapone Treatment Modulates Hippocampal Proteins Related to Synaptic Vehicle Trafficking

Cells, 2020
Entacapone, a reversible inhibitor of catechol-O-methyl transferase, is used for patients in Parkinson’s disease because it increases the bioavailability and effectiveness of levodopa.
Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang   +9 more
doaj   +1 more source

Mechanistic insights into mutually exclusive splicing in dynamin 1 [PDF]

Bioinformatics, 2013
Abstract Summary: Mutually exclusive splicing is a strictly regulated pattern of alternative splicing. A specific group of mutually exclusive splicing events has been shown to be regulated by the formation of specific RNA secondary structures. This type of regulation has been shown to exist only in arthropods.
openaire   +2 more sources

Dynamin I phosphorylation and the control of synaptic vesicle endocytosis. [PDF]

Biochemical Society Symposia, 2005
The GTPase dynamin I is essential for synaptic vesicle endocytosis in nerve terminals. It is a nerve terminal phosphoprotein that is dephosphorylated on nerve terminal stimulation by the calcium-dependent protein phosphatase calcineurin and then rephosphorylated by cyclin-dependent kinase 5 on termination of the stimulus.
Karen J, Smillie, Michael A, Cousin
openaire   +2 more sources

Molecular mechanism of DRP1 assembly studied in vitro by cryo-electron microscopy.

PLoS ONE, 2017
Mitochondria are dynamic organelles that continually adapt their morphology by fusion and fission events. An imbalance between fusion and fission has been linked to major neurodegenerative diseases, including Huntington's, Alzheimer's, and Parkinson's ...
Kaustuv Basu, Driss Lajoie, Tristan Aumentado-Armstrong, Jin Chen, Roman I Koning, Blaise Bossy, Mihnea Bostina, Attila Sik, Ella Bossy-Wetzel, Isabelle Rouiller   +9 more
doaj   +1 more source

Interaction of SPIN90 with Dynamin I and Its Participation in Synaptic Vesicle Endocytosis [PDF]

The Journal of Neuroscience, 2005
SH3 protein interacting with Nck, 90 kDa (SPIN90) is an Nck-binding protein that contains one Src homology 3 (SH3) domain, three proline-rich domains (PRDs), a serine/threonine-rich region, and a hydrophobic C-terminal region. Previously, we have shown that SPIN90 plays roles in the sarcomere assembly in cardiac muscles and in the formation of focal ...
Yujin, Kim, Sunyun, Kim, Suho, Lee, Sung Hyun, Kim, Yoonju, Kim, Zee Yong, Park, Woo Keun, Song, Sunghoe, Chang   +7 more
openaire   +2 more sources