Results 11 to 20 of about 28,974 (239)
Autophagy Reports, 2023 Macroautophagy/autophagy is a degradative pathway that plays an important role in maintaining cellular homeostasis in eukaryotes. During autophagy, cisternal compartments called phagophores are generated to sequester intracellular components; these ...
Yan Hu, Fulvio Reggiori
doaj +1 more source
Microorganisms, 2022 Peptidoglycan (PGN), a polymeric glycan macromolecule, is a major constituent of the bacterial cell wall and a conserved pathogen-associated molecular pattern (PAMP) that triggers immune responses through cytosolic sensors.
Narcis I. Popescu +5 more
doaj +1 more source
Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. [PDF]
PLoS ONE, 2013 Heart failure due to diastolic dysfunction exacts a major economic, morbidity and mortality burden in the United States. Therapeutic agents to improve diastolic dysfunction are limited. It was recently found that Dynamin related protein 1 (Drp1) mediates
Danchen Gao +5 more
doaj +1 more source
Interactions of Phocein with Nucleoside-Diphosphate Kinase, Eps15, and Dynamin I [PDF]
Journal of Biological Chemistry, 2002 Phocein, an intracellular protein interacting with striatin, bears a few homologies with the sigma-subunits of clathrin adaptor proteins (Baillat, G., Moqrich, A., Castets, F., Baude, A., Bailly, Y., Benmerah, A., and Monneron, A. (2001) Mol. Biol. Cell 12, 663-673).
Gilbert, Baillat +3 more
openaire +2 more sources
Marine Drugs, 2023 Marine algae extracts are an important area of potential drug discovery; however, nearly all studies to date have used non-fluorescent-based methods to determine changes in target cell activity. Many of the most robust immunological and cellular analyses
Laurie A. Minns +4 more
doaj +1 more source
Nitric oxide regulates endocytosis by S -nitrosylation of dynamin [PDF]
Proceedings of the National Academy of Sciences, 2006 The GTPase dynamin regulates endocytic vesicle budding from the plasma membrane, but the molecular mechanisms involved remain incompletely understood. We report that dynamin, which interacts with NO synthase, is S -nitrosylated at a single cysteine residue (C607) after stimulation of the β
Gaofeng, Wang +4 more
openaire +2 more sources
Journal of Molecular Pathology, 2022 Periodontitis is a chronic inflammatory disease characterized by the destruction of the supporting structures of the teeth. Its high prevalence and negative effects on quality of life make it one of the current problems in dentistry.
Elena A. Oleinik, Anna V. Goncharenko
doaj +1 more source
Nodal‐mediated epigenesis requires dynamin‐mediated endocytosis [PDF]
Developmental Dynamics, 2011 AbstractNodal proteins are diffusible morphogens that drive pattern formation via short‐range feedback activation coupled to long‐range Lefty‐mediated inhibition. In the sea urchin embryo, specification of the secondary (oral‐aboral) axis occurs via zygotic expression of nodal, which is localized to the prospective oral ectoderm at early blastula stage.
Robin P, Ertl +3 more
openaire +2 more sources
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023 Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
wiley +1 more source
Bezafibrate Improves Mitochondrial Fission and Function in DNM1L-Deficient Patient Cells
Cells, 2020 Mitochondria are involved in many cellular processes and their main role is cellular energy production. They constantly undergo fission and fusion, and these counteracting processes are under strict balance. The cytosolic dynamin-related protein 1, Drp1,
Liza Douiev +3 more
doaj +1 more source