Results 91 to 100 of about 4,214 (243)

Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis [PDF]

, 2011
Depolarization of nerve terminals stimulates rapid dephosphorylation of two isoforms of dynamin I (dynI), mediated by the calcium-dependent phosphatase calcineurin (CaN).
Aimee E. Novelle, Andersson, Anggono, Anggono, Aramburu, Aramburu, Bauerfeind, Beals, Cao, Chan, Chan, Chen-Hwang, Cheung, Clayton, Clayton, Clayton, Clayton, Clayton, Cousin, Cousin, Czirják, Czirják, Dell'Acqua, Engisch, Evans, Filosto, Garcia-Cozar, Graham, Granseth, Huang, Jain, Jing Xue, Jockusch, Jovanovic, Karen J. Smillie, Kasprowicz, Kim, Klee, Klee, Lai, Lai, LaPointe, Mark A. McNiven, Mark E. Graham, Marks, Michael A. Cousin, Nancy Sue, Newton, Noah Gray, Okamoto, Okamura, Perrino, Phillip J. Robinson, Rao, Robinson, Robinson, Ruiz-Velasco, Rusnak, Song, Stemmer, Sun, Tan, Wang, Wu, Ye, Yu, Zhang   +66 more
core   +1 more source

Synaptic Vesicle Dynamics sans Dynamin [PDF]

Neuron, 2007
The neuron-specific guanosine triphosphatase dynamin 1 has been hypothesized to be critically required for pinching off synaptic vesicles during endocytosis. In a recent publication in Science, Ferguson et al. describe a series of experiments demonstrating an unexpectedly selective requirement of dynamin 1 in synaptic vesicle endocytosis only during ...
openaire   +4 more sources

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling [PDF]

, 2011
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling.
Abdi, Agarwal, Allen, Anamika, Behnke, Billker, Billker, Bishop, Blethrow, Bracchi-Ricard, Bradley, Brian M. Cooke, Butcher, Carruthers, Carvalho, Christian Doerig, Cooke, Cooke, Coppi, Dalpke, Daniel C. Lim, Dar, Doerig, Doerig, Doerig, Dorin, Dorin, Dorin, Droucheau, El Hajj, Fennell, Fentress, Gilbert, Green, Gueirard, Halbert, Hanks, Huse, Hutti, Ishino, Jensen, Jeroen P.J. Saeij, Kafsack, Kannan, Kato, Khaminets, Khan, Khan, Khan, Kieschnick, Kun, Kuo, Labesse, Ling, Lodoen, Lourido, Luder, Manning, Martens, Melzer, Nagamune, Nunes, Nunes, Ojo, Ong, Parsons, Peixoto, Pernas, Qiu, Reese, Reese, Reese, Reininger, Reininger, Reininger, Rosenberg, Rosowski, Saeij, Saeij, Scheibel, Schneider, Shiels, Sicard, Singh, Singh, Solyakov, Sopko, Steinfeldt, Sugi, Suss-Toby, Taylor, Taylor, Tewari, Vaid, van de Sand, Ward, Ward, Wernimont, Wernimont, Xu, Yamamoto, Yasukawa, Zeqiraj, Zeqiraj, Zhao, Zhao   +105 more
core   +2 more sources

Dynamin and receptor‐mediated endocytosis [PDF]

FEBS Letters, 1996
The internalization of receptor‐bound ligands involves concentration of cell surface receptors in specialized areas of the plasma membrane and subsequent formation of clathrin‐coated vesicles. The complex process of invagination, constriction and budding of clathrin‐coated vesicles employs the coordinated actions of several proteins.
openaire   +2 more sources

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Synergistic association of STX1A and VAMP2 with cryptogenic epilepsy in North Indian population [PDF]

, 2016
Introduction “Common epilepsies”, merely explored for genetics are the most frequent, nonfamilial, sporadic cases in hospitals. Because of their much debated molecular pathology, there is a need to focus on other neuronal pathways including the existing ...
Baghel, Ruchi, Grover, Sandeep, Jajodia, Ajay, Kaur, Harpreet, Parween, Shama, Sinha, Juhi, Srivastava, Achal, Srivastava, Ankit   +7 more
core   +1 more source

Membrane curvature controls dynamin polymerization [PDF]

Proceedings of the National Academy of Sciences, 2010
The generation of membrane curvature in intracellular traffic involves many proteins that can curve lipid bilayers. Among these, dynamin-like proteins were shown to deform membranes into tubules, and thus far are the only proteins known to mechanically drive membrane fission.
Roux, Aurelien, Koster, Gerbrand, Lenz, Martin, Sorre, Benoît, Manneville, Jean-Baptiste, Nassoy, Pierre, Bassereau, Patricia   +6 more
openaire   +4 more sources

Reconstituting ring-rafts in bud-mimicking topography of model membranes. [PDF]

, 2014
During vesicular trafficking and release of enveloped viruses, the budding and fission processes dynamically remodel the donor cell membrane in a protein- or a lipid-mediated manner.
Jeon, Noo Li, Jordan, Luke R, Lee, Byoungho, Lee, In-Ho, Lee, Sin-Doo, Oh, Sang-Hyun, Oh, Soojung, Parikh, Atul N, Park, Seung Chul, Ryu, Yong-Sang, Suh, Jeng-Hun, Wittenberg, Nathan J   +11 more
core   +2 more sources

Long‐Read Genome Sequencing Establishes Biallelic Pathogenic Variants in DNM1 With Distinct Functional Effects as the Cause of Early Infantile Developmental and Epileptic Encephalopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous de novo and inherited biallelic pathogenic variants in DNM1 have been reported in association with autosomal dominant (AD) and autosomal recessive (AR) developmental and epileptic encephalopathy, respectively, due to aberrant dynamin function or expression, with each inheritance pattern associated with a different mechanism of ...
Andy Drackley, Merlene Peter, Heba H. Akbari, Jelena Ivanisevic, Alexander Ing, Kelly Regan‐Fendt, Patrick McMullen, Kai Lee Yap   +7 more
wiley   +1 more source