Identification of novel NPRAP/δ-catenin-interacting proteins and the direct association of NPRAP with dynamin 2. [PDF]
PLoS ONE, 2011 Neural plakophilin-related armadillo protein (NPRAP or δ-catenin) is a neuronal-specific protein that is best known for its interaction with presenilin 1 (PS1).
Carolina Koutras, Georges Lévesque
doaj +1 more source
Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis [PDF]
, 2011 Depolarization of nerve terminals stimulates rapid dephosphorylation of two isoforms of dynamin I (dynI), mediated by the calcium-dependent phosphatase calcineurin (CaN).
Aimee E. Novelle +66 more
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
LeoA, B and C from enterotoxigenic Escherichia coli (ETEC) are bacterial dynamins.
PLoS ONE, 2014 Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion.
Katharine A Michie +4 more
doaj +1 more source
Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. [PDF]
, 2019 Cells have evolved diverse protein-based machinery to reshape, cut, or fuse their membrane-delimited compartments. Dynamin superfamily proteins are principal components of this machinery and use their ability to hydrolyze GTP and to polymerize into ...
Frost, Adam, Kalia, Raghav
core
Dynamin function is important for chemokine receptor-induced cell migration. [PDF]
, 2015 The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis ...
Arai +38 more
core +1 more source
Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms [PDF]
The Journal of Cell Biology, 1998 A role for dynamin in clathrin-mediated endocytosis is now well established. However, mammals express three closely related, tissue-specific dynamin isoforms, each with multiple splice variants. Thus, an important question is whether these isoforms and splice variants function in vesicle formation from distinct intracellular organelles.
Altschuler, Yoram +6 more
openaire +4 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages. [PDF]
PLoS ONE, 2014 Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that ...
Maaike Kockx +9 more
doaj +1 more source
Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2 [PDF]
, 2017 Gab2 is a large disordered protein that regulates several cellular signalling pathways and is overexpressed in different forms of cancer. Because of its disordered nature, a detailed characterization of the mechanisms of recognition between Gab2 and ...
Bonetti, Daniela +3 more
core +3 more sources