Results 41 to 50 of about 4,246 (265)

Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation

eLife, 2022
The formation of a clathrin-coated vesicle (CCV) is a major membrane remodeling process that is crucial for membrane traffic in cells. Besides clathrin, these vesicles contain at least 100 different proteins although it is unclear how many are essential ...
Cansu Küey, Méghane Sittewelle, Gabrielle Larocque, Miguel Hernández-González, Stephen J Royle   +4 more
doaj   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

PLoS ONE, 2017
Prion diseases are neurodegenerative conditions characterized by the conformational conversion of the cellular prion protein (PrPC), an endogenous membrane glycoprotein of uncertain function, into PrPSc, a pathological isoform that replicates by imposing
Claudia Stincardini, Tania Massignan, Silvia Biggi, Saioa R Elezgarai, Valeria Sangiovanni, Ilaria Vanni, Michael Pancher, Valentina Adami, Jorge Moreno, Matteo Stravalaci, Giulia Maietta, Marco Gobbi, Alessandro Negro, Jesús R Requena, Joaquín Castilla, Romolo Nonno, Emiliano Biasini   +16 more
doaj   +1 more source

Defective membrane remodeling in neuromuscular diseases: insights from animal models. [PDF]

PLoS Genetics, 2012
Proteins involved in membrane remodeling play an essential role in a plethora of cell functions including endocytosis and intracellular transport. Defects in several of them lead to human diseases.
Belinda S Cowling, Anne Toussaint, Jean Muller, Jocelyn Laporte   +3 more
doaj   +1 more source

Dynamin 2 Cooperates with Amphiphysin 1 in Phagocytosis in Sertoli Cells [PDF]

, 2008
Testicular Sertoli cells highly express dynamin 2 and amphiphysin 1. Here we demonstrate that dynamin 2 is implicated in phosphatidylserine (PS)-dependent phagocytosis in Sertoli cells. Immunofluorescence and dual-live imaging revealed that dynamin 2 and
Abe, Tadashi, Nakanishi, Akira, Takei, Kohji, Watanabe, Masami, Yamada, Hiroshi   +4 more
core   +1 more source

F-actin Bundle Sedimentation Assay

Bio-Protocol, 2019
Understanding the molecular mechanism governing the higher-order regulation of actin dynamics requires chemically-defined and quantitative assays. Recently, the membrane remodeling large GTPase, dynamin, has been identified as a new actin cross-linking ...
Shan-Shan Lin, Mei-Chun Chuang, Ya-Wen Liu   +2 more
doaj   +1 more source

A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression [PDF]

, 2018
The mode of action of trans-resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in ...
Ciudad i Gómez, Carlos Julián, Franco Fernández, Rafael, Martín, Mairena, Martínez-Pinilla, Eva, Navarro Brugal, Gemma, Noé Mata, Verónica, Ortiz, Raquel, Sánchez Melgar, Alejandro   +7 more
core   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Syntaphilin Binds to Dynamin-1 and Inhibits Dynamin-dependent Endocytosis [PDF]

Journal of Biological Chemistry, 2003
Syntaphilin is a brain-specific syntaxin-binding partner first characterized as an inhibitor of SNARE complex formation and neurotransmitter release. Here we show that syntaphilin also binds to dynamin-1 and through this interaction inhibits dynamin-mediated endocytosis. Immunoprecipitation studies from cross-linked rat synaptosomes demonstrate that an
Sunit, Das, Claudia, Gerwin, Zu-Hang, Sheng   +2 more
openaire   +2 more sources