Results 71 to 80 of about 4,209 (249)

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

The advantage of channeling nucleotides for very processive functions [version 2; referees: 3 approved]

F1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala, Uwe Schlattner, Thomas Desvignes, Julien Bobe, Aurélien Roux, Philippe Chavrier, Mathieu Boissan   +6 more
doaj   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

The advantage of channeling nucleotides for very processive functions [version 1; referees: 3 approved]

F1000Research, 2017
Nucleoside triphosphate (NTP)s, like ATP (adenosine 5’-triphosphate) and GTP (guanosine 5’-triphosphate), have long been considered sufficiently concentrated and diffusible to fuel all cellular ATPases (adenosine triphosphatases) and GTPases (guanosine ...
Diana Zala, Uwe Schlattner, Thomas Desvignes, Julien Bobe, Aurélien Roux, Philippe Chavrier, Mathieu Boissan   +6 more
doaj   +1 more source

A noncanonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells. [PDF]

PLoS Biology, 2018
Dynamin Guanosine Triphosphate hydrolases (GTPases) are best studied for their role in the terminal membrane fission process of clathrin-mediated endocytosis (CME), but they have also been proposed to regulate earlier stages of CME.
Saipraveen Srinivasan, Christoph J Burckhardt, Madhura Bhave, Zhiming Chen, Ping-Hung Chen, Xinxin Wang, Gaudenz Danuser, Sandra L Schmid   +7 more
doaj   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Dynamin function is important for chemokine receptor-induced cell migration. [PDF]

, 2015
The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis ...
Arai, Bachelerie, Borroni, Casoli, Chua, De Camilli, Delgado-Martin, Drury, Ferguson, Gallo, Germena, Harper, Harper, Hill, Homey, Kawada, Kerr, Lagane, Lee, Loetscher, Magalhaes, Mariani, McCluskey, McGeachie, Meiser, Mueller, Mueller, Mueller, Rajagopal, Rajagopal, Sabroe, Scott, Shpetner, Tadagaki, Thelen, Tomizawa, Zhang, Zlotnik, Zlotnik   +38 more
core   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

The role of dynamin-related proteins in vacuole biogenesis in fission yeast (Schizosaccharomyces pombe) : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2008
Dynamins are GTPases concerned with membrane tubulation and scission (Praefcke and McMahon, 2004). In the fission yeast, Schizosaccharomyces pombe, the dynamin-related proteins (DRPs) Vps1 and Dnm1 act redundantly in peroxisome biogenesis (Jourdain et al.
Röthlisberger, Sarah Ruth
core