Results 81 to 90 of about 4,214 (243)

Dynamin-related proteins in plant post-Golgi traffic

Frontiers in Plant Science, 2014
Membrane traffic between two organelles begins with the formation of transport vesicles from the donor organelle. Dynamin-related proteins (DRPs), which are large multidomain GTPases, play crucial roles in vesicle formation in post-Golgi traffic ...
Masaru eFujimoto, Nobuhiro eTsutsuimi
doaj   +1 more source

The role of dynamin-related proteins in vacuole biogenesis in fission yeast (Schizosaccharomyces pombe) : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2008
Dynamins are GTPases concerned with membrane tubulation and scission (Praefcke and McMahon, 2004). In the fission yeast, Schizosaccharomyces pombe, the dynamin-related proteins (DRPs) Vps1 and Dnm1 act redundantly in peroxisome biogenesis (Jourdain et al.
Röthlisberger, Sarah Ruth
core  

Ubiquitination in Control of EGF Receptor Endocytosis [PDF]

, 2008
Growth factors and growth factor receptors comprise a signaling network regulating cell differentiation and growth. Tightly regulation of this network is important to avoid excessive signaling and cell growth, which may result in cancer.
Bertelsen, Vibeke
core   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Dynamin function is important for chemokine receptor-induced cell migration. [PDF]

, 2015
The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis ...
Arai, Bachelerie, Borroni, Casoli, Chua, De Camilli, Delgado-Martin, Drury, Ferguson, Gallo, Germena, Harper, Harper, Hill, Homey, Kawada, Kerr, Lagane, Lee, Loetscher, Magalhaes, Mariani, McCluskey, McGeachie, Meiser, Mueller, Mueller, Mueller, Rajagopal, Rajagopal, Sabroe, Scott, Shpetner, Tadagaki, Thelen, Tomizawa, Zhang, Zlotnik, Zlotnik   +38 more
core   +1 more source

Kalirin12 interacts with dynamin

BMC Neuroscience, 2009
Abstract Background Guanine nucleotide exchange factors (GEFs) and their target Rho GTPases regulate cytoskeletal changes and membrane trafficking. Dynamin, a large force-generating GTPase, plays an essential role in membrane tubulation and fission in cells. Kalirin12, a neuronal RhoGEF, is found in growth cones early
Mains Richard E, Rabiner Chana A, Xin Xiaonan, Eipper Betty A   +3 more
openaire   +3 more sources

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification [PDF]

Journal of Applied Oral Science
Objective For treatment of medication-related osteonecrosis of the jaw, one proposed approach is the use of a topical agent to block entry of these medications in oral soft tissues.
Jacob KIRBY, Makayla STANDFEST, Jessica BINKLEY, Charles BARNES, Evan BROWN, Tyler CAIRNCROSS, Alex CARTWRIGHT, Danielle DADISMAN, Colten MOWAT, Daniel WILMOT, Theodore HOUSEMAN, Conner MURPHY, Caleb ENGELSMAN, Josh HALLER, Daniel JONES   +14 more
doaj   +1 more source

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor

Cell Communication and Signaling, 2020
Background Lymphotoxin β receptor (LTβR) is a member of tumor necrosis factor receptor (TNFR) superfamily which regulates the immune response. At the cellular level, upon ligand binding, the receptor activates the pro-inflammatory NF-κB and AP-1 pathways.
Małgorzata Maksymowicz, Marta Miączyńska, Magdalena Banach-Orłowska   +2 more
doaj   +1 more source