Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior [PDF]
, 2017 Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-like and aversive behavior. While some information is known about the afferent circuitry that endogenously drives this neural activity and behavior, the downstream ...
Bhatti, Dionnet L. +6 more
core +3 more sources
Involvement of dynorphin in anxiogenic effects of estrogen
BMC Pharmacology, 2009 Methods Dyn KO mice were generated by replacement of the entire coding region of the prodynorphin gene [2] and backcrossed onto C57bl/6N. Age and testing experiencematched female intact and ovariectomized (OVX) Dyn KO and wildtype (WT) mice at 3-8 months age were tested in all experiments.
Christoph Schwarzer +3 more
openaire +2 more sources
Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference [PDF]
, 2013 Stress increases the risk of drug abuse, causes relapse to drug seeking, and potentiates the rewarding properties of both nicotine and cocaine. Understanding the mechanisms by which stress regulates the rewarding properties of drugs of abuse provides ...
Al-Hasani, Ream +2 more
core +2 more sources
Rising plasma nociceptin level during development of HCC: A case report [PDF]
, 2004 AIM: Although liver cirrhosis is a predisposing factor for hepatocellular carcinoma (HCC), relatively few reports are available on HCC in primary biliary cirrhosis.
Folhoffer, Anikó +8 more
core +1 more source
The degradation of dynorphin A in brain tissue in vivo and in vitro [PDF]
, 1987 Elizabeth A. Young +3 more
openalex +1 more source
Frontiers in Molecular Neuroscience, 2012 The brain is constantly exposed to external and internal input and to function in an ever-changing environment we are dependent on processes that enable the brain to adapt to new stimuli.
Ingrid eNylander, Erika eRoman
doaj +1 more source
Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists [PDF]
, 2016 It has now been demonstrated that the μ, δ(1), δ(2), and κ(1) opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R ...
Bailey A +64 more
core +1 more source
Detection and Mapping of Quantitative Trait Loci that Determine Responsiveness [PDF]
, 2004 Exposure to 70% N2O evokes a robust antinociceptive effect in C57BL/6 (B6) but not in DBA/2 (D2) inbred mice. This study was conducted to identify quantitative trait loci (QTL) in the mouse genome that might determine responsiveness to N2O.
Belknap, John K. +4 more
core +1 more source
Nicotine Increases Alcohol Intake in Adolescent Male Rats [PDF]
, 2017 Background: Use of alcohol and tobacco, the two most concurrently abused drugs, typically first occurs during adolescence. Yet, there have been no systematic analyses of ethanol (EtOH) and nicotine (Nic) interactions during adolescence.
Armando Lárraga +2 more
core +1 more source
Electrophysiological effects of dynorphin peptides on hippocampal pyramidal cells in rat [PDF]
, 1985 Hylan C. Moises, James M. Walker
openalex +1 more source