Neural Plasticity, 2020 Background. Visceral pain is one of the most common types of pain and particularly in the abdomen is associated with gastrointestinal diseases. Bulleyaconitine A (BAA), isolated from Aconitum bulleyanum, is prescribed in China to treat chronic pain.
Sheng-Nan Huang +5 more
doaj +1 more source
Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis [PDF]
, 2011 Background There is a growing realization that alterations in host-pathogen interactions (HPI) can generate disease phenotypes without pathogen invasion. The gut represents a prime region where such HPI can arise and manifest.
John B Seal +3 more
core +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 3, March 2026.Targeting stress‐escalated alcohol drinking could help patients with alcohol use disorder (AUD). We found that reducing the activity of the epigenetic regulatory enzyme G9a (aka euchromatic histone‐lysine N‐methyltransferase 2 or EHMT2) by repeated systemic administration of a G9a inhibitor reduces stress‐escalated ethanol drinking in a mouse model ...
Deltrice Holmes +4 more
wiley +1 more source
Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides [PDF]
, 2015 Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ...
Beaudry, Francis, Saidi, Mouna
core +1 more source
Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition
bioRxiv, 2021 A. D. Abraham +8 more
semanticscholar +1 more source
Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]
, 2019 Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
core +1 more source
Journal of Neuroscience, 2015 We employ transgenic mice with selective expression of tdTomato or cre recombinase together with optogenetics to investigate whether hypothalamic arcuate (ARC) dopamine/tyrosine hydroxylase (TH) neurons interact with other ARC neurons, how they respond ...
Xiaobing Zhang, A. N. van den Pol
semanticscholar +1 more source
Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder
Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley +1 more source
Role of movement in long-term basal ganglia changes: implications for abnormal motor responses
Frontiers in Computational Neuroscience, 2013 Abnormal involuntary movements and dyskinesias elicited by drugs that stimulate dopamine receptors in the basal ganglia are a major issue in the management of Parkinson’s disease (PD).
Nicola eSimola +6 more
doaj +1 more source
Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception [PDF]
, 2004 Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating ...
DiPirro, Jean M., Kristal, Dr. Mark B.
core