Results 111 to 120 of about 23,741 (299)
Membrane leakage induced by dynorphins
FEBS Letters, 2006 Dynorphins, endogeneous opioid peptides, function as ligands to the opioid kappa receptors and induce non‐opioid excitotoxic effects. Here we show that big dynorphin and dynorphin A, but not dynorphin B, cause leakage effects in large unilamellar phospholipid vesicles (LUVs).
Hugonin, Loïc +3 more
openaire +2 more sources
Obesity Reviews, Volume 27, Issue 1, Page 1-21, January 2026.ABSTRACT Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic–pituitary–ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The risk of complications during pregnancy, such as gestational diabetes mellitus (GDM) and preeclampsia (PE)
Shaohua Zhang +5 more
wiley +1 more source
Frontiers in Pain ResearchIntroductionSleep disturbances have been shown to exacerbate pain sensitivity and prolong recovery from pain. However, conventional animal models of sleep disturbance, which involve physical disruptions, such as water or forced movement, might not fully ...
Hisakatsu Ito +5 more
doaj +1 more source
Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides [PDF]
, 2016 Background During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti- inflammatory M2 populations ...
Batra, Arvind +6 more
core +2 more sources
Clinical Pharmacology in Drug Development, Volume 14, Issue 12, Page 934-950, December 2025.Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi +8 more
wiley +1 more source
Capillary HPLC Separation of Selected Neuropeptides [PDF]
, 2012 Neuropeptides play a pivotal role in brain and peripheral nervous system function. As high performance liquid chromatography (HPLC) becomes the central tool in the separation and characterization of peptide and protein samples, its selectivity ...
Yi, Ying
core
Health Science Reports, Volume 8, Issue 12, December 2025.ABSTRACT Background and Aims Uterine fibroids are noncancerous growths of myometrium cells. Seeking for advantageous methods to alleviate their debilitating symptoms is of extreme importance. Acupuncture with global reach could be a beneficial treatment method for uterine fibroids.
Elham Hooshyarazar +6 more
wiley +1 more source
Low Degree of Overlap Between Kisspeptin, Neurokinin B, and Dynorphin Immunoreactivities in the Infundibular Nucleus of Young Male Human Subjects Challenges the KNDy Neuron Concept. [PDF]
, 2012 Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis ...
Borsay, Beáta Ágnes +7 more
core +1 more source
Electroacupuncture as a treatment for suspected trigeminal nerve‐mediated head‐shaking in 42 horses
Equine Veterinary Education, Volume 37, Issue 12, Page 647-653, December 2025.Summary Background Electroacupuncture (EA) has been used successfully as a treatment for trigeminal nerve‐mediated head‐shaking (TMHS) in a small case series, but results from a larger number of cases are lacking. Objectives To retrospectively investigate the effectiveness of EA as a treatment for horses with TMHS.
B. Dunkel +5 more
wiley +1 more source
Neural Plasticity, 2020 Background. Visceral pain is one of the most common types of pain and particularly in the abdomen is associated with gastrointestinal diseases. Bulleyaconitine A (BAA), isolated from Aconitum bulleyanum, is prescribed in China to treat chronic pain.
Sheng-Nan Huang +5 more
doaj +1 more source