Results 121 to 130 of about 23,741 (299)

Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models

open access: yesJournal of Neuroinflammation, 2016
Aconiti brachypodi Radix (Xue-shang-yi-zhi-hao) has been prescribed to manage chronic pain, arthritis, and traumatic injuries. Bullatine A, a C20-diterpenoid alkaloid, is one of its principle effective compounds.
Qian Huang   +6 more
semanticscholar   +1 more source

The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma [PDF]

open access: gold, 2022
Suhjung Janet Lee   +7 more
openalex   +1 more source

The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]

open access: yes, 2012
Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
core   +2 more sources

Advanced Biomaterial Delivery of Hypoxia‐Conditioned Extracellular Vesicles (EVs) as a Therapeutic Platform for Traumatic Brain Injury

open access: yesAdvanced Science, Volume 12, Issue 44, November 27, 2025.
This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein   +9 more
wiley   +1 more source

Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance.

open access: yesBrain : a journal of neurology, 2022
Hisakatsu Ito   +17 more
semanticscholar   +1 more source

Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception [PDF]

open access: yes, 2004
Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating ...
DiPirro, Jean M., Kristal, Dr. Mark B.
core  

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]

open access: yes, 2017
Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar   +15 more
core   +2 more sources

Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH‐RH in Teleosts

open access: yesBioEssays, Volume 47, Issue 11, November 2025.
Regarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Daichi Kayo   +3 more
wiley   +1 more source

Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition

open access: yesbioRxiv, 2021
Antony D. Abraham   +8 more
semanticscholar   +1 more source

Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides [PDF]

open access: yes, 2015
Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ...
Beaudry, Francis, Saidi, Mouna
core   +1 more source

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