Results 91 to 100 of about 18,230 (213)
eLife, 2016 Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1ARH) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide ...
Jian Qiu +6 more
doaj +1 more source
Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides [PDF]
, 2016 Background During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti- inflammatory M2 populations ...
Batra, Arvind +6 more
core +2 more sources
British Journal of Pharmacology, Volume 182, Issue 22, Page 5596-5610, November 2025.Background and Purpose In some individuals, opioid use leads to decreased interest in socially relevant rewards. Recent studies showed that after extended‐access heroin self‐administration, rats strongly prefer social interaction over single unit‐dose heroin infusions.
Ginevra D'Ottavio +12 more
wiley +1 more source
Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]
, 1995 Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core +1 more source
Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides [PDF]
, 2015 Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ...
Beaudry, Francis, Saidi, Mouna
core +1 more source
Alcohol, Clinical and Experimental Research, Volume 49, Issue 10, Page 2267-2277, October 2025.Targeting dependence‐ and/or stress‐escalated alcohol drinking could help patients with alcohol use disorder (AUD). We found that reducing the activity of the epigenetic regulatory enzyme G9a (aka euchromatic histone‐lysine N‐methyltransferase 2 or EHMT2) either by a viral knockdown in the nucleus accumbens (NAc) or by repeated systemic administration ...
Marcelo F. Lopez +4 more
wiley +1 more source
Journal of Neuroinflammation, 2020 Background Isotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-inflammatory, anti-rheumatic, and ...
Shuai Shao +10 more
doaj +1 more source
Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception [PDF]
, 2004 Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating ...
DiPirro, Jean M., Kristal, Dr. Mark B.
core
Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]
, 2017 Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Alkass, Kanar +15 more
core +2 more sources
Pain Perception and Modulation: Fundamental Neurobiology and Recent Advances
European Journal of Neuroscience, Volume 62, Issue 8, October 2025.Chronic pain is a major burden with variable treatment responses reflecting complex biopsychosocial and neurobiological factors. This narrative review synthesizes evidence on neural structures, circuits, and mediators involved in pain perception and modulation.
Willem W. J. van Strien +1 more
wiley +1 more source