Results 61 to 70 of about 8,125 (179)

Dynorphin-dependent reduction of excitability and attenuation of inhibitory afferents of NPS neurons in the pericoerulear region of mice

Frontiers in Cellular Neuroscience, 2016
The Neuropeptide S system, consisting of the 20-amino acid peptide neuropeptide S (NPS) and its G-protein coupled receptor (NPSR), modulates arousal, wakefulness, anxiety, and fear-extinction in mice.
Kay eJuengling, Peter eBlaesse, Lena eGoedecke, Hans-Christian ePape   +3 more
doaj   +1 more source

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, Volume 4, Issue 1, Page 15-28, March 2026.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression

Journal of Neuroinflammation, 2020
Background Isotalatizidine is a representative C19-diterpenoid alkaloid extracted from the lateral roots of Aconitum carmichaelii, which has been widely used to treat various diseases on account of its analgesic, anti-inflammatory, anti-rheumatic, and ...
Shuai Shao, Huan Xia, Min Hu, Chengjuan Chen, Junmin Fu, Gaona Shi, Qinglan Guo, Yu Zhou, Wenjie Wang, Jiangong Shi, Tiantai Zhang   +10 more
doaj   +1 more source

Synergistic Effect of Combination Treatment of Brexpiprazole and Nalmefene on Ethanol Intake in Rats

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
Combination effect of nalmefene and brexpiprazole on ethanol intake in rats. The combination of subeffective doses of nalmefene (0.04 mg/kg, s.c.) and brexpiprazole (0.01 mg/kg, p.o.) significantly and synergistically decreased the average ethanol intake for 4 days compared with before the treatment (interaction effect: p = 0.0033 by two‐way ANOVA ...
Naoki Amada, Mai Nakamura, Yuta Ohgi, Yusuke Kakumoto, Mikio Suzuki, Takashi Futamura, Kenji Maeda   +6 more
wiley   +1 more source

Antianalgesic Action of Dynorphin A Mediated by Spinal Cholecystokinin

Experimental Biology and Medicine, 1999
Previous work indicates that the antianalgesic action of pentobarbital and neurotensin administered intracerebroventricularly in mice arises from activation of a descending system to release cholecystokinin (CCK) in the spinal cord where CCK is known to antagonize morphine analgesia.
J J, Rady, B B, Holmes, J M, Fujimoto
openaire   +2 more sources

Elevated CSF dynorphin A [1–8] in Tourette's syndrome

Life Sciences, 1988
A recent neuropathological study has reported decreased levels of dynorphin A immunoreactivity in striato-pallidal fibers in the brain of a patient with severe Gilles de la Tourette's syndrome (TS). This observation, taken with the neuroanatomic distribution of dynorphin and its broad range of motor and behavioral effects, has led to speculation ...
J F, Leckman, M A, Riddle, W H, Berrettini, G M, Anderson, M, Hardin, P, Chappell, G, Bissette, C B, Nemeroff, W K, Goodman, D J, Cohen   +9 more
openaire   +2 more sources

Malnutrition alters protein expression of KNDy neuropeptides in the arcuate nucleus of mature ewes

Frontiers in Physiology
The neuropeptides kisspeptin, neurokinin B, and dynorphin A are imperative for the pulsatile secretion of gonadotropin-releasing hormone and luteinizing hormone to ultimately regulate reproductive cyclicity.
Jennifer F. Thorson, Ligia D. Prezotto
doaj   +1 more source

Perivascular expression and potent vasoconstrictor effect of dynorphin A in cerebral arteries.

PLoS ONE, 2012
BackgroundNumerous literary data indicate that dynorphin A (DYN-A) has a significant impact on cerebral circulation, especially under pathophysiological conditions, but its potential direct influence on the tone of cerebral vessels is obscure. The aim of
Éva Ruisanchez, Attila Cselenyák, Rege Sugárka Papp, Tamás Németh, Krisztina Káldi, Péter Sándor, Zoltán Benyó   +6 more
doaj   +1 more source

Influence of dynorphin A (1-13) and dynorphin A (1-10) amide on stress-induced analgesia.

Physiological research, 1997
Dynorphin A (1-13) and its analog dynorphin A (1-10) amide were applied intracerebroventricularly in male ICR mice. Both dynorphins did not reveal any analgesic activity in tail-flick test under normal (non-stressed) conditions. However, in combination with stress (forced swimming or whole body vibration) both dynorphins prolonged tail-flick latencies ...
M, Starec, J, Rosina, J, Málek, M, Krsiak   +3 more
openaire   +1 more source

Discovery of Amphipathic Dynorphin A Analogues to Inhibit the Neuroexcitatory Effects of Dynorphin A through Bradykinin Receptors in the Spinal Cord

Journal of the American Chemical Society, 2014
We hypothesized that under chronic pain conditions, up-regulated dynorphin A (Dyn A) interacts with bradykinin receptors (BRs) in the spinal cord to promote hyperalgesia through an excitatory effect, which is opposite to the well-known inhibitory effect of opioid receptors.
Lee, Yeon Sun, Muthu, Dhanasekaran, Hall, Sara M., Ramos-Colon, Cyf, Rankin, David, Hu, Jackie, Sandweiss, Alexander J., De Felice, Milena, Xie, Jennifer Yanhua, Vanderah, Todd W., Porreca, Frank, Lai, Josephine, Hruby, Victor J.   +12 more
openaire   +2 more sources