Results 71 to 80 of about 22,550,361 (272)
SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]
BAG. Journal of Basic and Applied Genetics, 2020 Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F. +2 more
doaj +1 more source
Journal of Neuroscience, 1986 Male Fischer-344 rats were given a single intrastriatal injection of kainic acid (KA; 1 microgram/rat), which caused recurrent motor seizures lasting 3–6 hr.
T. Kanamatsu +6 more
semanticscholar +1 more source
Mechanism and site of action of big dynorphin on ASIC1a [PDF]
Proceedings of the National Academy of Sciences, 2019 Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great interest in understanding the in vivo regulation of ASICs, especially by endogenous neuropeptides that potently modulate ASICs.
Borg, Christian B. +13 more
openaire +7 more sources
Bulleyaconitine A Exerts Antianxiety and Antivisceral Hypersensitivity Effects
Frontiers in Pharmacology, 2020 Visceral pain is one of the leading causes for abdominal pain in gastroenterological diseases and is still hard to treat effectively. Bulleyaconitine A (BAA) is an aconitine analog and has been used for the treatment of pain.
Sheng-Nan Huang +12 more
doaj +1 more source
Dynorphin induced magnetic ordering in lipid bilayers as studied by 31P NMR spectroscopy [PDF]
, 2002 Lipid bilayers of dimyristoyl phosphatidylcholine (DMPC) containing opioid peptide dynorphin A(1–17) are found to be spontaneously aligned to the applied magnetic field near at the phase transition temperature between the gel and liquid crystalline ...
Nagao, Takashi +7 more
core +1 more source
Journal of Neuroscience, 1990 The endogenous opioid dynorphin A-(1-17) (Dyn A) has been implicated as a mediator of tissue damage after traumatic spinal cord injury (TSCI) and causes hindlimb paralysis when administered intrathecally.
R. Bakshi, A. Newman, A. Faden
semanticscholar +1 more source
Hepatoprotective effect of opioid peptides in stress [PDF]
Research Results in Pharmacology, 2019 Introduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress ...
Alexey V. Solin +2 more
doaj +3 more sources
Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion-extension movements [PDF]
, 2008 The present research investigates factors contributing to bradykinesia in the control of simple and complex voluntary limb movement in Parkinson’s disease (PD) patients.
Geelen, J.A.G. +3 more
core +4 more sources
Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides
Biomedicines, 2021 Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb +6 more
doaj +1 more source
Capillary HPLC Separation of Selected Neuropeptides [PDF]
, 2012 Neuropeptides play a pivotal role in brain and peripheral nervous system function. As high performance liquid chromatography (HPLC) becomes the central tool in the separation and characterization of peptide and protein samples, its selectivity ...
Yi, Ying
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