Results 71 to 80 of about 8,125 (179)

Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study

International Journal of Reproductive BioMedicine
Background: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Andon Hestiantoro, Rachellina Noor Al Maghfira, Ratna Fathmasari, Ririn Rahmala Febri, Ericko Ongko Joyo, Raden Muharam, Gita Pratama, Anom Bowolaksono   +7 more
doaj   +1 more source

Structural basis of divergent substrate recognition and inhibition of human neurolysin

Scientific Reports
A zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln ...
Ke Shi, Sounak Bagchi, Jordis Bickel, Shiva H. Esfahani, Lulu Yin, Tiffany Cheng, Vardan T. Karamyan, Hideki Aihara   +7 more
doaj   +1 more source

Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease.

PLoS ONE, 2011
L-DOPA-induced dyskinesia is a troublesome complication of L-DOPA pharmacotherapy of Parkinson's disease and has been associated with disturbed brain opioid transmission.
Anna Ljungdahl, Jörg Hanrieder, Maria Fälth, Jonas Bergquist, Malin Andersson   +4 more
doaj   +1 more source

Dose-effect relationship between electroacupuncture with different parameters and the regulation of endogenous opioid peptide system

World Journal of Acupuncture - Moxibustion
Endogenous opioid peptides (EOP) are the neurochemical basis of the anesthetic and analgesic effects of acupuncture, and the quantity of acupuncture stimulus can be controlled accurately by using electroacupuncture (EA).
Ping CHEN, Hong XU, Ren ZHANG, Xue-song TIAN   +3 more
doaj   +1 more source

Purification and Biochemical Characterization of TsMS 3 and TsMS 4: Neuropeptide-Degrading Metallopeptidases in the Tityus serrulatus Venom

Toxins, 2019
Although omics studies have indicated presence of proteases on the Tityus serrulatus venom (TsV), little is known about the function of these molecules.
Daniela Cajado-Carvalho, Cristiane Castilho Fernandes da Silva, Roberto Tadashi Kodama, Douglas Oscar Ceolin Mariano, Daniel Carvalho Pimenta, Bruno Duzzi, Alexandre Kazuo Kuniyoshi, Fernanda Vieira Portaro   +7 more
doaj   +1 more source

Epigenetic Regulation of Spinal Cord Gene Expression Controls Opioid-Induced Hyperalgesia

Molecular Pain, 2014
Background: The long term use of opioids for the treatment of pain leads to a group of maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves within few days after cessation of morphine treatment in mice but is prolonged ...
De-Yong Liang, Yuan Sun, Xiao-You Shi, Peyman Sahbaie, J David Clark   +4 more
doaj   +1 more source

A genetic polymorphism of the endogenous opioid dynorphin modulates monetary reward anticipation in the corticostriatal loop.

PLoS ONE, 2014
The dynorphin/κ-opioid receptor (KOP-R) system has been shown to play a role in different types of behavior regulation, including reward-related behavior and drug craving.
Mikhail Votinov, Mikhail Votinov, Juergen Pripfl, Christian Windischberger, Klaudius Kalcher, Alexander Zimprich, Fritz Zimprich, Ewald Moser, Claus Lamm, Uta Sailer   +9 more
doaj   +1 more source

Interaction between corticotropin-releasing factor, orexin, and dynorphin in the infralimbic cortex may mediate exacerbated alcohol-seeking behavior

Neurobiology of Stress
A major challenge for the treatment of alcohol use disorder (AUD) is relapse to alcohol use, even after protracted periods of self-imposed abstinence. Stress significantly contributes to the chronic relapsing nature of AUD, given its long-lasting ability
Francisco J. Flores-Ramirez, Jessica M. Illenberger, Rémi Martin-Fardon   +2 more
doaj   +1 more source

Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons

Nature Communications
The hippocampus is pivotal in integrating emotional processing, learning, memory, and reward-related behaviors. The dorsal hippocampus (dHPC) is particularly crucial for episodic, spatial, and associative memory, and has been shown to be necessary for ...
Khairunisa Mohamad Ibrahim, Nicolas Massaly, Hye-Jean Yoon, Rossana Sandoval, Allie J. Widman, Robert J. Heuermann, Sidney Williams, William Post, Sulan Pathiranage, Tania Lintz, Azra Zec, Ashley Park, Waylin Yu, Thomas L. Kash, Robert W. Gereau, Jose A. Morón   +15 more
doaj   +1 more source

A dynorphin theory of depression and bipolar disorder

Major depressive disorder (MDD) is a debilitating health condition affecting a substantial part of the world's population. At present, there is no biological theory of MDD, and treatment is partial at best. Here I present a theory of MDD that explains its etiology, symptoms, pathophysiology, and treatment.
openaire   +2 more sources