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Annual Review of Pharmacology and Toxicology, 1988
Like other opioids, the dynorphins play a role in wide variety of physiological parameters, including pain regulation, motor activity, cardiovascular regulation, respiration, temperature regulation, feeding behavior, hormone balance, and the response to shock or stress. The dynorphins are unusual if not unique, however, in that they frequently modulate
A P, Smith, N M, Lee
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Like other opioids, the dynorphins play a role in wide variety of physiological parameters, including pain regulation, motor activity, cardiovascular regulation, respiration, temperature regulation, feeding behavior, hormone balance, and the response to shock or stress. The dynorphins are unusual if not unique, however, in that they frequently modulate
A P, Smith, N M, Lee
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Progress in Neurobiology, 1996
Studies on dynorphin involvement in epilepsy are summarised in this review. Electrophysiological, biochemical and pharmacological data support the hypothesis that dynorphin is implicated in specific types of seizures. There is clear evidence that this is true for complex partial (limbic) seizures, i.e.
Simonato M., Romualdi P.
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Studies on dynorphin involvement in epilepsy are summarised in this review. Electrophysiological, biochemical and pharmacological data support the hypothesis that dynorphin is implicated in specific types of seizures. There is clear evidence that this is true for complex partial (limbic) seizures, i.e.
Simonato M., Romualdi P.
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Nonopiate Effects of Dynorphin and Des-Tyr-Dynorphin
Science, 1982Intracerebroventricular administration of dynorphin produced potent and long-lasting effects on motor function and the electroencephalogram in rats. In addition, local iontophoretic or pressure ejection of dynorphin consistently inhibited hippocampal unit activity.
J M, Walker +4 more
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Biochemical and Biophysical Research Communications, 1983
Rimorphin (dynorphin B) has been demonstrated to exist together with alpha-neo-endorphin and dynorphin(1-17) (dynorphin A) in the human hypothalamus. The content of rimorphin was comparable to that of alpha-neo-endorphin and somewhat higher than that of dynorphin. This result is quite similar to the recent observations in bovine, porcine and rat neural
K, Nakao +6 more
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Rimorphin (dynorphin B) has been demonstrated to exist together with alpha-neo-endorphin and dynorphin(1-17) (dynorphin A) in the human hypothalamus. The content of rimorphin was comparable to that of alpha-neo-endorphin and somewhat higher than that of dynorphin. This result is quite similar to the recent observations in bovine, porcine and rat neural
K, Nakao +6 more
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Journal of Neurochemistry, 1986
AbstractDynorphin B (rimorphin) is formed from leumorphin (dynorphin B‐29) by the action of a thiol protease from rat brain membranes, in a single step. This represents a “single‐arginine cleavage” between threonine‐13 and arginine‐14 of the substrate. We have observed that in addition to dynorphin B, dynorphin B‐14 is formed from dynorphin B‐29. Among
L, Devi, A, Goldstein
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AbstractDynorphin B (rimorphin) is formed from leumorphin (dynorphin B‐29) by the action of a thiol protease from rat brain membranes, in a single step. This represents a “single‐arginine cleavage” between threonine‐13 and arginine‐14 of the substrate. We have observed that in addition to dynorphin B, dynorphin B‐14 is formed from dynorphin B‐29. Among
L, Devi, A, Goldstein
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European Journal of Pharmacology, 1989
In both rats and humans there is an analgesia associated with pregnancy. This analgesia is spinally mediated and involves the kappa type of opiate receptor. The current study demonstrates that intrathecal administration of high affinity dynorphin antibodies produces a significant reduction in jump thresholds during pregnancy (day 20).
H W, Sander, R M, Kream, A R, Gintzler
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In both rats and humans there is an analgesia associated with pregnancy. This analgesia is spinally mediated and involves the kappa type of opiate receptor. The current study demonstrates that intrathecal administration of high affinity dynorphin antibodies produces a significant reduction in jump thresholds during pregnancy (day 20).
H W, Sander, R M, Kream, A R, Gintzler
openaire +2 more sources