Dysfibrinogenemia and hypofibrinogenemia - Spectrum of pathogenic variants in Slovak patients
Biomedical PapersIntroduction. Congenital hypofibrinogenemia (CH) and congenital dysfibrinogenemia (CD) are rare coagulation disorders caused by quantitative or qualitative defects in the fibrinogen gene.
Dominika Jaraskova +11 more
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Washington University Record, November 14, 1991 [PDF]
, 1991 https://digitalcommons.wustl.edu/record/1566/thumbnail ...
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Veterinary Clinical Pathology, Volume 54, Issue 2, Page 120-131, June 2025.ABSTRACT Background To date, no studies have reported the evaluation of hemostatic activity in canine leukoreduced cryoprecipitate (LR‐CRYO) and leukoreduced cryopoor plasma (LR‐CPP). Objectives We aimed to compare the hemostatic activity of LR‐CRYO and LR‐CPP to leukoreduced fresh plasma (LR‐FP) and to evaluate the preservation of LR‐CRYO by ...
Roberta Perego +7 more
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Phenotype, genotype, and laboratory assessment of congenital fibrinogen disorders:Data from the Rare Bleeding disorders in the Netherlands study [PDF]
Introduction: Congenital fibrinogen disorders (CFDs), encompassing quantitative (hypo−/afibrinogenemia) and qualitative (dysfibrinogenemia) defects, can result in bleeding or thrombotic events.
Blijlevens, Nicole M.A. +11 more
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Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (BβAla68Thr), showed almost entirely normal polymerization [PDF]
, 2018 ArticleTHROMBOSIS RESEARCH.172:1-3(2018)journal ...
Arai, Shinpei +5 more
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Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT To investigate the prevalence, clinical manifestations, and risk factors of hypofibrinogenemia after tigecycline use, which can disrupt coagulation and potentially hinder antimicrobial therapy. This observational study was conducted from January to December 2021 at a tertiary general hospital in China.
Xiaohui Liu +5 more
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Novel heterozygous dysfibrinogenemia, Sumida (A alpha C472S), showed markedly impaired lateral aggregation of protofibrils and mildly lower functional fibrinogen levels [PDF]
, 2015 Introduction: We encountered a 6-year-old girl with systemic lupus erythematosus. Although no bleeding or thrombotic tendency was detected, routine coagulation screening tests revealed slightly lower plasma fibrinogen levels, as determined by functional ...
Arai, Shinpei +5 more
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Acquired hypofibrinogenemia: current perspectives
Journal of Blood Medicine, 2016 Martin W Besser,1 Stephen G MacDonald2 1Department of Haematology, 2Department of Specialist Haemostasis, The Pathology Partnership, Addenbrooke’s Hospital, Cambridge, UK Abstract: Acquired hypofibrinogenemia is most frequently caused by ...
Besser MW, MacDonald SG
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Frontiers in Pediatrics, 2020 Pediatric Acute Liver Failure (PALF) is a rapidly progressive clinical syndrome encountered in the pediatric ICU which may rapidly progress to multi-organ dysfunction, and on occasion to life threatening cerebral edema and hemorrhage.
Yonca Bulut, Anil Sapru, Gavin D. Roach
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c.259A>C in the fibrinogen gene of alpha chain (FGA) is a fibrinogen with thrombotic phenotype
The Application of Clinical Genetics, 2019 Ophira Salomon,1 Ortal Barel,2 Eran Eyal,2 Reut Shnerb Ganor,3 Yeroham Kleinbaum,4 Mordechai Shohat2 1Institute of Thrombosis and Hemostasis, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 2Cancer Research ...
Salomon O +5 more
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