Results 31 to 40 of about 123,648 (399)

Temporal discrimination: Mechanisms and relevance to adult-onset dystonia [PDF]

, 2017
Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as ...
Beck, Rebecca, Conte, Antonella, Hutchinson, Michael, Killian, Owen, Mcgovern, Eavan M., Narasimham, Shruti, O'Riordan, Sean, Reilly, Richard B.   +7 more
core   +1 more source

Development of a highly sensitive immunohistochemical method to detect neurochemical molecules in formalin-fixed and paraffin-embedded tissues from autopsied human brains

Frontiers in Neuroanatomy, 2015
Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase).
Satoshi eGoto, Satoshi eGoto, Satoshi eGoto, Ryoma eMorigaki, Shinya eOkita, Shinji eNagahiro, Ryuji eKaji   +6 more
doaj   +1 more source

Rapid-onset dystonia-parkinsonism

Definitions, 2020
Rapid-onset dystonia parkinsonism is a rare movement disorder. "Rapid-onset" refers to the abrupt appearance of signs and symptoms over a period of hours to days.

semanticscholar   +1 more source

Putaminal mosaic visualized by tyrosine hydroxylase immunohistochemistry in the human neostriatum.

Frontiers in Neuroanatomy, 2016
Among the basal ganglia-thalamocortical circuits, the putamen plays a critical role in the ‘motor’ circuits that control voluntary movements and motor learning.
Ryoma eMorigaki, Satoshi eGoto
doaj   +1 more source

A History of Dystonia: Ancient to Modern [PDF]

, 2017
Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to ...
Deborah Thorpe, Jane Alty, Peter Kempster, Rachel Newby   +3 more
core   +1 more source

Plasticity and dystonia: a hypothesis shrouded in variability. [PDF]

, 2020
Studying plasticity mechanisms with Professor John Rothwell was a shared highlight of our careers. In this article, we discuss non-invasive brain stimulation techniques which aim to induce and quantify plasticity, the mechanisms and nature of their ...
A Albanese, A Berardelli, A Conte, A Guerra, A Guerra, A Karabanov, A Karabanov, A Latorre, A Quartarone, A Quartarone, A Quartarone, A Quartarone, A Quartarone, A Quartarone, A Sadnicka, A Sadnicka, A Sadnicka, Anna Sadnicka, B Balint, B Cheeran, B Hordacre, C Ganos, C Terranova, D Belvisi, D Weise, F Fratello, F Pierelli, G Abbruzzese, H Eggink, HA Jinnah, HR Siebner, JF Muller-Dahlhaus, JS Kang, K Stefan, KM Fedak, KP Bhatia, L Ozelius, M Hamada, M Hamada, M Kojovic, M Pellegrini, Masashi Hamada, MC Ridding, N Patel, NH Jung, RG Carson, S Meunier, S Wiethoff, SA Schneider, V Lopez-Alonso, V Lopez-Alonso, YZ Huang, YZ Huang   +52 more
core   +1 more source

Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders

Brain : a journal of neurology, 2020
Dystonia is a neurological disorder characterized by sustained or intermittent muscle contractions causing abnormal movements and postures, often occurring in absence of any structural brain abnormality.
N. Mencacci, R. Reynolds, Sonia Garcia Ruiz, J. Vandrovcova, P. Forabosco, Á. Sánchez-Ferrer, V. Volpato, J. Botía, Karishma D’Sa, P. Forabosco, S. Guelfi, J. Hardy, J. Vandrovcova, Chris-Ann Mackenzie, A. Ramasamy, M. Ryten, Colin Smith, D. Trabzuni, M. Weale, A. Noyce, R. Kaiyrzhanov, B. Middlehurst, D. Kia, M. Tan, H. Houlden, H. Morris, H. Plun-Favreau, P. Holmans, J. Bras, J. Quinn, K. Mok, K. J. Kinghorn, Kimberley J. Billingsley, N. Wood, P. Lewis, R. Guerreiro, R. Lovering, L. R'bibo, C. Manzoni, M. Rizig, V. Escott-Price, V. Chelban, T. Foltynie, N. Williams, Chingiz Shashakin, N. Zharkinbekova, Elena Zholdybayeva, A. Aitkulova, K. Harvey, M. Weale, K. Bhatia, C. Webber, J. Hardy, J. Botía, M. Ryten   +54 more
semanticscholar   +1 more source

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity

Brain Sciences, 2017
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Ryoma Morigaki, Satoshi Goto
doaj   +1 more source

Video analysis of patients with blepharospasm and lower face dystonias

Dystonia, 2023
Background: Blepharospasm (BSP) is a focal dystonia. There is a lack of standardization in the length of time necessary to get a measure of BSP severity for rating scales.Objectives: 1) Determine the difference between evaluating the number of eye ...
Mahdieh Hosseini, Mahdieh Hosseini, Panagiotis Kassavetis, Panagiotis Kassavetis, Mark Hallett   +4 more
doaj   +1 more source

Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins

Toxins, 2020
Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum ...
T. Hassell, D. Charles
semanticscholar   +1 more source