Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies
Advanced Science, Volume 12, Issue 14, April 10, 2025.This review article delves into the cutting‐edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a thorough examination of recent developments that have addressed key challenges in the field, including improved precision, enhanced editing efficiency, and ...
Abhijith Koodamvetty +1 more
wiley +1 more source
Direct visualization of the dystrophin network on skeletal muscle fiber membrane. [PDF]
, 1992 Volker Straub +3 more
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Aggregate, Volume 6, Issue 4, April 2025.Here we present a high‐resolution mass spectrometry‐based proteomics study, unravelling the molecular signatures evoked on human skeletal muscle‐derived pericytes after 3D rotary wet‐spinning (RoWS) biofabrication deposition. The presented work characterises for the very first time the molecular routes that are activated/inhibited in the 2D or 3D ...
Alessio Reggio +17 more
wiley +1 more source
Binding sites involved in the interaction of actin with the N‐terminal region of dystrophin [PDF]
, 1992 Barry A. Levine +3 more
openalex +1 more source
A Homozygous MYH1 Variant Underlies Autosomal Recessive Isolated Recurrent Rhabdomyolysis
American Journal of Medical Genetics Part A, Volume 197, Issue 4, April 2025.ABSTRACT Rhabdomyolysis is a severe condition involving the breakdown of skeletal muscle fibers, leading to the release of muscle components into the bloodstream, which can lead to potential complications such as acute kidney injury and electrolyte imbalances.
Eyyup Uctepe +5 more
wiley +1 more source
Identification of a novel first exon in the human dystrophin gene and of a new promoter located more than 500 kb upstream of the nearest known promoter. [PDF]
, 1994 Hisahide Nishio +9 more
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Cancer Medicine, Volume 14, Issue 8, April 2025.ABSTRACT Background Genetic testing and sequencing technologies offer a comprehensive understanding of cancer genetics, providing rapid and cost‐effective solutions. In particular, these advanced technologies play an important role in assessing the complexities of the rare cancer types affecting several systems including the bone, endocrine, digestive,
Joviana Farhat +4 more
wiley +1 more source
A homologue of dystrophin is expressed at the neuromuscular junctions of normal individuals and DMD patients, and of normal and mdx mice Immunological evidence [PDF]
, 1991 F. Pons +9 more
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ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely +14 more
wiley +1 more source
Localization of dystrophin gene transcripts during mouse embryogenesis. [PDF]
, 1992 Denis Houzelstein +3 more
openalex +1 more source