Results 111 to 120 of about 23,636 (243)
In vitro degradation of the Duchenne muscular dystrophy gene product (dystrophin)
Kiichiro Matsumura+2 more
openalex +2 more sources
Dystrophin is phosphorylated by endogenous protein kinases [PDF]
Monica De Luise+8 more
openalex +1 more source
ABSTRACT Background Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron‐dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy remains unclear. Methods Ferroptosis in skeletal muscle atrophy was investigated using two
Shunshun Han+8 more
wiley +1 more source
Isolation and characterization of different C-terminal fragments of dystrophin expressed in Escherichia coli [PDF]
R E Milner+2 more
openalex +1 more source
ABSTRACT Background Quantitative muscle MRI commonly evaluates disease activity and muscle wasting in Duchenne muscular dystrophy (DMD). Disturbances in ion homeostasis contribute to DMD pathophysiology, but their relationships with disease progression is unclear. 23Na MRI may provide insights into the disease course and treatment response.
Teresa Gerhalter+8 more
wiley +1 more source
Myotubes from transgenic mdx mice expressing full-length dystrophin show normal calcium regulation. [PDF]
W F Denetclaw+4 more
openalex +1 more source
Incidence of Radiologically Confirmed Fractures in Adults With Duchenne Muscular Dystrophy
ABSTRACT Introduction/Aims An increased risk of low trauma fractures is well documented in children and adolescents with duchenne muscular dystrophy (DMD). There is limited evidence regarding the fracture incidence of adults with DMD. The aim of this study was to examine radiologically confirmed fractures in adults with DMD and review bone health ...
Gavin Langlands+3 more
wiley +1 more source
Dystrophin in a membrane skeletal network: localization and comparison to other proteins [PDF]
GM Dmytrenko, D W Pumplin, RJ Bloch
openalex +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review
Abstract In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new chemical entities were approved, the number of ‘orphan’ drug authorisations in 2024 (21) is ...
Stavros Topouzis+16 more
wiley +1 more source