Results 21 to 30 of about 18,651,759 (343)

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.

Genes & Development, 2008
Cancer progression has similarities with the process of epithelial-to-mesenchymal transition (EMT) found during embryonic development, during which cells down-regulate E-cadherin and up-regulate Vimentin expression.
Sun-Mi Park, A. Gaur, E. Lengyel, M. Peter   +3 more
semanticscholar   +1 more source

Actin cytoskeleton regulation of epithelial mesenchymal transition in metastatic cancer cells. [PDF]

PLoS ONE, 2015
Epithelial-mesenchymal transition (EMT) is associated with loss of the cell-cell adhesion molecule E-cadherin and disruption of cell-cell junctions as well as with acquisition of migratory properties including reorganization of the actin cytoskeleton and
Jay Shankar, Ivan R Nabi
doaj   +1 more source

The functional activity of E-cadherin controls tumor cell metastasis at multiple steps

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The expression of E-cadherin has been implicated in tumor metastasis, often as a tumor suppressor, but also as a promoter of growth and metastasis.
T. Na, L. Schecterson, Alisha M. Mendonsa, B. Gumbiner   +3 more
semanticscholar   +1 more source

The absence of early malignant changes in women subjected to Aquafilling breast augmentation on the basis of E-cadherin and N-cadherin immunohistochemical expression

Central European Journal of Immunology, 2023
The use of Aquafilling can be associated with a variety of health complications. The filler is an inflammatory process trigger at the site of tissue contact.
Michał Chalcarz, Jakub Żurawski
doaj   +1 more source

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Cells, 2019
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness.
C. Loh, J. Chai, T. F. Tang, W. Wong, G. Sethi, M. Shanmugam, P. Chong, C. Looi   +7 more
semanticscholar   +1 more source

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

Cell Reports, 2016
E-cadherin-mediated cell-cell junctions play a prominent role in maintaining the epithelial architecture. The disruption or deregulation of these adhesions in cancer can lead to the collapse of tumor epithelia that precedes invasion and subsequent ...
Zahra Erami, David Herrmann, Sean C. Warren, Max Nobis, Ewan J. McGhee, Morghan C. Lucas, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, James R.W. Conway, Claire Vennin, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Astrid Magenau, Kendelle J. Murphy, Rachel A. Ridgway, Andrew M. Law, Stacey N. Walters, Shane T. Grey, David R. Croucher, Lei Zhang, Herbert Herzog, Edna C. Hardeman, Peter W. Gunning, Christopher J. Ormandy, T.R. Jeffry Evans, Douglas Strathdee, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson   +33 more
doaj   +1 more source

WAVE facilitates polarized E-cadherin transport

Molecular Biology of the Cell, 2023
The Arp2/3 nucleation-promoting factor WAVE promotes cell protrusions and apicolateral enrichment of cadherin. Does it promote cadherin trafficking? Live imaging shows that endogenous WAVE and cadherin localize to recycling endosomes and Golgi and that WAVE supports polarized sorting of cadherin.
Luigy Cordova-Burgos, Deepti Rao, Joshua Egwuonwu, Sofya Borinskaya, Shashikala Sasidharan, Martha Soto   +5 more
openaire   +2 more sources

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2*

Journal of Biological Chemistry, 2008
MicroRNAs are small non-coding RNA molecules that can regulate gene expression by interacting with multiple mRNAs and inducing either translation suppression or degradation of mRNA.
M. Korpal, Esther S. Lee, G. Hu, Yibin Kang   +3 more
semanticscholar   +1 more source

Expression of E-, P- and N-Cadherin and Its Clinical Significance in Cervical Squamous Cell Carcinoma and Precancerous Lesions. [PDF]

PLoS ONE, 2016
Aberrant expression of classical cadherins has been observed in tumor invasion and metastasis, but its involvement in cervical carcinogenesis and cancer progression is not clear.
Baohua Li, Haiyan Shi, Fenfen Wang, Die Hong, Weiguo Lv, Xing Xie, Xiaodong Cheng   +6 more
doaj   +1 more source

Recycling of E-Cadherin [PDF]

The Journal of Cell Biology, 1999
E-Cadherin plays critical roles in many aspects of cell adhesion, epithelial development, and the establishment and maintenance of epithelial polarity. The fate of E-cadherin once it is delivered to the basolateral cell surface, and the mechanisms which govern its participation in adherens junctions, are not well understood. Using surface biotinylation
Tam Luan Le, Alpha S. Yap, Jennifer L. Stow   +2 more
openaire   +1 more source