Results 31 to 40 of about 18,651,759 (343)
E-cadherin is required for metastasis in multiple models of breast cancer
Nature, 2019 Metastasis is the major driver of death in patients with cancer. Invasion of surrounding tissues and metastasis have been proposed to initiate following loss of the intercellular adhesion protein, E-cadherin1,2, on the basis of inverse correlations ...
Veena Padmanaban +6 more
semanticscholar +1 more source
Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. [PDF]
PLoS ONE, 2010 Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes in cadherin expression (known as cadherin switching) are a common mechanism for ...
Laura J Lewis-Tuffin +6 more
doaj +1 more source
Regulation of E-cadherin [PDF]
Breast Cancer Online, 2005 Numerous studies suggest that loss of E-cadherin is necessary to induce Epithelial–mesenchymal transition (EMT) and metastasis. Snail is a major contributor to EMTs. The Snail family of zinc-finger transcription factors interact with the E-cadherin promoter to repress transcription during EMT.
Z. Yang, H. Zhang, R. Kumar
openaire +1 more source
Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis. [PDF]
PLoS ONE, 2012 Alpha (α)-E-catenin is a component of the cadherin complex, and has long been thought to provide a link between cell surface cadherins and the actin skeleton.
Sumeda Nandadasa +4 more
doaj +1 more source
E-Cadherin in Pancreatic Ductal Adenocarcinoma: A Multifaceted Actor during EMT
Cells, 2020 Epithelial-to-mesenchymal transition (EMT) is a step-wise process observed in normal and tumor cells leading to a switch from epithelial to mesenchymal phenotype.
M. Sommariva, N. Gagliano
semanticscholar +1 more source
PLoS ONE, 2012 The cadherin switch from E-cadherin to N-cadherin is considered as a hallmark of the epithelial-mesenchymal transition and progression of carcinomas. Although it enhances aggressive behaviors of adenocarcinoma cells, the significance and role of cadherin
Takashi Hashimoto +7 more
doaj +1 more source
Allosteric Regulation of E-Cadherin Adhesion [PDF]
Journal of Biological Chemistry, 2015 Cadherins are transmembrane adhesion proteins that maintain intercellular cohesion in all tissues, and their rapid regulation is essential for organized tissue remodeling. Despite some evidence that cadherin adhesion might be allosterically regulated, testing of this has been hindered by the difficulty of quantifying altered E-cadherin binding affinity
Nitesh, Shashikanth +8 more
openaire +2 more sources
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Nature Cell Biology, 2010 MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased ...
Li Ma +13 more
semanticscholar +1 more source
N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin. [PDF]
PLoS ONE, 2012 P120-catenin (p120ctn) exerts important roles in regulating E-cadherin and invasiveness in cancer cells. However, the mechanisms by which p120ctn isoforms 1 and 3 modulate E-cadherin expression are poorly understood.
Juanhan Yu +7 more
doaj +1 more source
5-Azacytidine Enhancing Expression of E-cadherin in Adenocarcinoma Cell Line
Archives of Advances in Biosciences, 2023 Introduction: In this study, we assessed the expression of E-cadherin in HT29 cell line treated with 5-Azacytidine and colorectal cancer patient in an Iranian population. E-cadherin expression promotes metastasis and prognosis of colorectal cancer (CRC).
Sanaz Savabkar +4 more
doaj +1 more source