Results 51 to 60 of about 18,651,759 (343)
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells
Journal of Cell Biology, 1991 The ability of carcinomas to invade and to metastasize largely depends on the degree of epithelial differentiation within the tumors, i.e., poorly differentiated being more invasive than well-differentiated carcinomas.
U. Frixen +5 more
semanticscholar +1 more source
Cancer: leaping the E‐cadherin hurdle [PDF]
The EMBO Journal, 2015 Aberrant activation of the Wnt signaling pathway is a common cause of colon cancer and other tumor types, accomplishing many of the hallmarks of cancer including sustained proliferative signaling, replicative immortality, reprogrammed metabolism, angiogenesis, and invasion.
Chen, GT, Waterman, ML
openaire +4 more sources
There are four dynamically and functionally distinct populations of E-cadherin in cell junctions
Biology Open, 2015 E-cadherin is a trans-membrane tumor suppressor responsible for epithelial cell adhesion. E-cadherin forms adhesive clusters through combined extra-cellular cis- and trans-interactions and intracellular interaction with the actin cytoskeleton.
Zahra Erami +4 more
doaj +1 more source
Indonesian Biomedical Journal, 2021 BACKGROUND: The absence of potential biomarkers to detect the metastatic process at an early stage will consequently delay colorectal cancer (CRC) treatment.
Winarko Luminturahardjo +4 more
doaj +1 more source
Paranuclear E-Cadherin in Gastric Adenocarcinoma [PDF]
American Journal of Clinical Pathology, 2002 Decreased E-cadherin expression permits dissociation and widespread dissemination of gastric adenocarcinoma cells. We studied the relationship between paranuclear E-cadherin distribution and the histopathologic characteristics of gastric adenocarcinomas.
Philip M, Carpenter +2 more
openaire +2 more sources
International Journal of Molecular Sciences, 2019 The epithelial–mesenchymal transition (EMT) is thought to be at the root of invasive and metastatic cancer cell spreading. E-cadherin is an important player in this process, which forms the structures that establish and maintain cell–cell interactions. A
I. Bure, M. Nemtsova, D. Zaletaev
semanticscholar +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
Nature Communications, 2018 The limitations of current anti-angiogenic therapies necessitate other targets with complimentary mechanisms. Here, we show for the first time that soluble E-cadherin (sE-cad) (an 80-kDa soluble form), which is highly expressed in the malignant ascites ...
Maggie K. S. Tang +8 more
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis
Nature Communications, 2018 During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal role in this process by providing persistent cell adhesion and by transmitting
Girish R. Kale +5 more
semanticscholar +1 more source