Results 71 to 80 of about 18,651,759 (343)

Low expression of E-Cadherin and <i>Cdh1</i> variants associated with diffuse gastric cancer [PDF]

, 2023
Azaria García-Ruvalcaba, Katia C Vázquez-Ibarra, María Teresa Magaña‐Torres, Lourdes Del C Rizo de-la-Torre, Lennon Meléndez-Aranda, Gabriela del Carmen López-Armas, José Alfonso Cruz-Ramos, Jorge Peregrina-Sandoval, Esther Espinoza-Jiménez, María Elena Rosales-Gradilla, Josefina Yoaly Sánchez-López   +10 more
openalex   +1 more source

E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning

Nature Communications, 2017
Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer.
M. Rübsam, A. Mertz, A. Kubo, S. Marg, C. Jüngst, Gladiola Goranci-Buzhala, A. Schauss, V. Horsley, E. Dufresne, M. Moser, W. Ziegler, M. Amagai, S. Wickström, C. Niessen   +13 more
semanticscholar   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Human Langerhans Cells Express E-Cadherin

Journal of Investigative Dermatology, 1995
Murine Langerhans cells (LC) synthesize and express E-cadherin, a Ca(++)-dependent homophilic cell adhesion molecule that mediates LC-keratinocyte (KC) binding in vitro. In vivo, E-cadherin expression by LC may promote localization and persistence of LC within the epidermis through LC-KC adhesion.
Blauvelt, Andrew, Katz, Stephen I., Udey, Mark C.   +2 more
openaire   +2 more sources

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

Nature Communications, 2017
Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue architecture, but it is unclear how they might be coordinated.
M. Gloerich, M. Gloerich, Julie M. Bianchini, K. Siemers, Daniel J. Cohen, W. Nelson   +5 more
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via β-catenin

Cell & Bioscience, 2022
Background Cadherins play a pivotal role in facilitating intercellular interactions between spermatogonial progenitor cells (SPCs) and their surrounding microenvironment.
Weixiang Song, Danchen Zhang, Jiaqi Mi, Wenfei Du, Yang Yang, Rong Chen, Cong Tian, Xiaodong Zhao, Kang Zou   +8 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells

Neoplasia: An International Journal for Oncology Research, 2008
E-cadherin is a main component of the cell-cell adhesion junctions that play a principal role in maintaining normal breast epithelial cell morphology. Breast and other cancers that have up-regulated activity of Ras are often found to have down-regulated ...
Quanwen Li, Raymond R. Mattingly
doaj   +1 more source

Impact of p120-catenin isoforms 1A and 3A on epithelial mesenchymal transition of lung cancer cells expressing E-cadherin in different subcellular locations. [PDF]

PLoS ONE, 2014
The epithelial mesenchymal transition (EMT) is an important process in tumor development. Despite previous investigations, it remains unclear how p120-catenin (p120ctn) isoforms 1A and 3A affect the EMT of tumor cells.
Yijun Zhang, Yue Zhao, Guiyang Jiang, Xiupeng Zhang, Huanyu Zhao, Junhua Wu, Ke Xu, Enhua Wang   +7 more
doaj   +1 more source