Results 91 to 100 of about 34,125,650 (293)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Demarcation of the Field of E-Government Assessment

open access: yesTransylvanian Review of Administrative Sciences, 2016
The assessment of e-government is a part of the appealing field of e-government which has recently attracted the attention of many researchers, who most of the time carry out measurements and evaluations of e-government maturity and do international ...
Mimoza BOGDANOSKA JOVANOVSKA
doaj   +2 more sources

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Digital public services: Catalysts for healthcare efficiency

open access: yesJournal of Open Innovation: Technology, Market and Complexity
Healthcare systems pose a continuous concern and challenge for countries worldwide. Effective governance plays a pivotal role in managing these systems, ensuring the well-being of current and future generations.
Aleksy Kwilinski   +3 more
doaj   +1 more source

e-Participation Platform for Facilitating Citizens Involvement in Smart City Initiatives [PDF]

open access: yesRevista Română de Informatică și Automatică, 2018
The increase in the world population and the massive migration of the population to the urban area give rise to new problems difficult to manage by the government and local authorities.
Ionuț PETRE   +2 more
doaj  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Challenges for E-Government Strategy [PDF]

open access: yes
Governments worldwide are faced with the challenge of transformation and the need to reinvent government systems in order to deliver efficient and cost effective services, information and knowledge through information and communication technologies ...
Mircea GEORGESCU
core  

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