Results 91 to 100 of about 811,801 (297)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

MENGUKUR ENGAGEMENT WARGA NEGARA DALAM INTERAKSI MEDIA SOSIAL (STUDI PADA 32 AKUN RESMI FACEBOOK PEMERINTAH KABUPATEN/KOTA DI JAWA TENGAH)

Jurnal Natapraja: Kajian Ilmu Administrasi Negara, 2019
The purpose of this research is to measure citizen engagement on social media interaction of 32 regencies/ municipals government official Facebook accounts in Central Java Province.To do so, a quantitative approach was conducted.
Anton Purwadi, Arif Budy Pratama, Raden Mas Mahendradi   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Modeling Services Acceptance Factors of Mobile Government (M-Government)

Asia-Pacific Journal of Information Technology and Multimedia, 2012
Advancement in information and communication technologies (ICTs), particularly the rapid changes in mobile technologies have led to development of new applications and services.
Ahmad Althunibat, Nor Azan Mat Zin, Noraidah Sahari @ Ashaari   +2 more
doaj   +1 more source

Development of System Architecture for E-Government Cloud Platforms

, 2016
Requirements and criteria for selection of cloud platform and platform visualization are stated by which optimal cloud products will be chosen for the Republic of Kazakhstan e-Government considering quality-price ratio, and also the framework of ...
Aubakirov, M., Nikulchev, E.
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A review of the status of e-government implementation in Kenya

Regional Journal of Information and Knowledge Management, 2017
Rationale of Study – Successful implementation of today’s government operations requires effective policy making and system monitoring through relevant data and information.
Esther Nderitu Imbamba, Nancy Kimile
doaj  

Unlocking E-Government Success: Key Factors Driving E-Absence Adoption in Public Sector

JAKPP (Jurnal Analisis Kebijakan dan Pelayanan Publik)
The use of e-absence for government servants is currently an innovative way to improve the efficiency of work activities in local government. The focus on how the system is implemented and used by government servants is also important to discuss.
Dedy Afrizal, Dila Erlianti, E. Maznah Hijeriah, Lis Hafrida, Erinaldi Erinaldi, Ahmad Luthfi   +5 more
doaj   +1 more source

A Model for Implementing Green E-Government Using the Fuzzy Cognitive Map Method [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī
The existence of challenges such as the continuous circulation of information, the active presence of governments in the online environment, ecological changes in work and lifestyle, and the problem of electronic wave pollution have made the role of ...
Mahdiye Ghorbani, Hossein Sayyadi, salim karimi takalo   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source