Results 71 to 80 of about 34,125,650 (293)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

E-Government Partnerships Across Levels of Government [PDF]

E-government Partnerships across Levels of Government, is an overview of the challenges and approaches to creating a collaborative and cooperative partnership across levels of government for e-government development and implementation.E-Governance ...
Michalun, Varinia, Charbit, Claire
core  

Freedom or Safety, the Dilemma of Technology-Based Surveillance Systems in the Context of E-Government

French Journal for Media Research, 2016
Cet article se propose de répondre aux questions suivantes : Les technologies de l'information renforcent-elles la position des citoyens face à l'État? La société obtient-elle une gouvernance plus démocratique en raison des applications du e-gouvernement?
AKGÜL Ali Erdem
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

E-Government vs. Ordinary Bureaucratic Government: A Comparative Study [PDF]

In this century, e-government is drawing significant attention especially in administration and business and in other service organizations. This paper attempts to clarify the terms e-government, e-governance and bureaucratic government. It also pays the
Bashar, Mohammad Rabiul, Razael, Karim Mohammed, Grout, Vic   +2 more
core  

Towards Inclusive E-Government

, 2013
In this chapter, five case studies of the implementation of contact centers in Swedish municipalities are described and discussed with a focus on inclusive e-government.
Kerstin Grundén, Grundén, Kerstin,, Irene Bernhard, Bernhard, Irene,, Grundén, K.   +4 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

E-GOVERNMENT DAN PENERAPANNYA

, 2017
RINGKASAN E-Government oleh PBB didefinisikan sebagai penggunaan teknologi informasi dan komunikasi dan penerapannya oleh pemerintah untuk menyediakan informasi dan layanan publik kepada masyarakat.
Igif G. Prihanto
core