Results 81 to 90 of about 34,125,650 (293)

A review of the status of e-government implementation in Kenya

open access: yesRegional Journal of Information and Knowledge Management, 2017
Rationale of Study – Successful implementation of today’s government operations requires effective policy making and system monitoring through relevant data and information.
Esther Nderitu Imbamba, Nancy Kimile
doaj  

Semantic frameworks for e-government

open access: yesProceedings of the 1st international conference on Theory and practice of electronic governance, 2007
This paper explains how semantic frameworks can be used to support successful e-Government initiatives by connecting system design to a shared understanding of interactions and processes. It shows how metadata standards and repositories can be used to establish and maintain such an understanding, and how they can be used in the automatic generation and
Charles Crichton   +4 more
openaire   +4 more sources

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

DoS Attacks and E-Government

open access: yes, 2007
The use of electronic technologies in government services has played a significant role in making citizens’ lives more convenient. Even though the transition to digital governance has great advantages for the quality of government services it may be ...
Douligeris, Christos   +1 more
core  

Unlocking E-Government Success: Key Factors Driving E-Absence Adoption in Public Sector

open access: yesJAKPP (Jurnal Analisis Kebijakan dan Pelayanan Publik)
The use of e-absence for government servants is currently an innovative way to improve the efficiency of work activities in local government. The focus on how the system is implemented and used by government servants is also important to discuss.
Dedy Afrizal   +5 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

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