Results 101 to 110 of about 811,801 (297)

e-Participation Platform for Facilitating Citizens Involvement in Smart City Initiatives [PDF]

open access: yesRevista Română de Informatică și Automatică, 2018
The increase in the world population and the massive migration of the population to the urban area give rise to new problems difficult to manage by the government and local authorities.
Ionuț PETRE   +2 more
doaj  

Cross-Cultural Analysiis of European e-Government Adoption [PDF]

open access: yes
In terms of adoption, the topic of e-government has focused on the supply side (or government-related issues) such as strategies and policy, challenges, technical issues, evaluation of the usability of e-government Websites; however, less attention has ...
Aykut, Arslan
core   +1 more source

The world experience of e-government: technological and semantic requirements for information systems [PDF]

open access: yes, 2016
В данной статье расматривается представление о мировом опыте государственного регулирования в области государственных информационных систем, понимать причины необходимости такого регулирования.This work is considered to the world experience of e ...
Nurjabova, D. Sh.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A conceptual model for semantically-based e-government portals [PDF]

open access: yes, 2005
Issues of semantic interoperability and service integration for e-government portals are the domain of interest of the present paper. We propose a Conceptual Model for One-Stop e-Government Portals based on the Semantic Web Service technology.
Cabral, Liliana   +3 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Home - About - Disclaimer - Privacy