Results 51 to 60 of about 34,125,650 (293)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Comparative Study of the International Index of E-government Development within different Geographical Regions of the World [PDF]
دولتپژوهی, 2018 Different spheres of human life as a result of the emergence and spread of the phenomenon of "Internet" has changed. "E-government" covers all platforms and applications of ICT that services citizens, businesses, other government agencies and civil ...
Yashar Zaki, Javad Hassanzadeh
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Introducing the municipal digital offering index for evaluating online services and addressing the digital divide [PDF]
PeerJ Computer ScienceThis research introduces the Municipal Digital Offering Index (MDOI) to assess municipal online service development in Chile. The study utilizes content analysis of municipal websites, creating a systematic instrument to evaluate digital services.
Carolina Busco +5 more
doaj +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Local Government Regional Management Plan - Northern Region
, 2012 Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).'The Plan is set out in five sections. Background provides an overview of legislative requirements of Regional Management Plans.
Local Government Support Unit
core
Model E-Government Pada Wilayah Administrasi Pemerintahan Tingkat Kelurahan
Jurnal Komputer Terapan, 2016 Belum sepenuhnya pemerintahan lokal di Indonesia menjadikan e-Government sebagai ujung tombak pemerintahan. Padahal, dengan komitmen yang kuat dari pemimpin daerah, penerapan TIK dapat menjawab tantangan global (seperti: Pasar Bebas ASEAN) dan kebutuhan
Satria Perdana Arifin +1 more
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source