Results 51 to 60 of about 24,017,194 (312)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Sovremennye Issledovaniâ Socialʹnyh Problem, 2014 This article analyzes the existing methods of e-government systems audit, their shortcomings are examined. The approaches to improve existing techniques and adapt them to the specific characteristics of e-government systems are suggested.
Евгений Геннадьевич Панкратов
doaj
Why Open Government Data? The Case of a Swedish Municipality
Journal of Data and Information Science, 2021 The purpose of this exploratory study is to provide modern local governments with potential use cases for their open data, in order to help inform related future policies and decision-making.
Golub Koraljka, Lund Arwid
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
E-government: A comparison of strategies in local authorities in the UK and Norway [PDF]
, 2006 In Europe almost all countries have implemented some form of e-government, not to mention the UK and Norway which are now both well into their sixth year of e-government implementation.
Jones, S, Olsen, E
core
Effectiveness of Electronic Government in the Citizen-Centric Approach in Bandung City
Mimbar, 2019 This paper aims to exploit e-government effectiveness from the perspective of users by focusing on online-based business licensing services in Bandung City.
Elisa Susanti +2 more
doaj +1 more source
Comparative Study of the International Index of E-government Development within different Geographical Regions of the World [PDF]
دولتپژوهی, 2018 Different spheres of human life as a result of the emergence and spread of the phenomenon of "Internet" has changed. "E-government" covers all platforms and applications of ICT that services citizens, businesses, other government agencies and civil ...
Yashar Zaki, Javad Hassanzadeh
doaj +1 more source