Results 81 to 90 of about 811,917 (322)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Situating the transient user: overcoming challenges in the design of e-government systems [PDF]

, 2005
e-Government systems present new challenges for user involvement in the design process. Existing user-centred and participatory design methodologies were mainly developed for situations where a user is in the workplace.
Inglesant, PG, Sasse, MA
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The world experience of e-government: technological and semantic requirements for information systems [PDF]

, 2016
В данной статье расматривается представление о мировом опыте государственного регулирования в области государственных информационных систем, понимать причины необходимости такого регулирования.This work is considered to the world experience of e ...
Nurjabova, D. Sh.
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Polyvinyl alcohol stabilized ZnS nanoaggregates using organosulfur source for photocatalytic disintegration of methyl orange dye

Results in Chemistry
ZnS nanoaggregates surface-passivated by a hydroxyl-based polymer matrix, polyvinyl alcohol (PVA), have been synthesized using a wet chemical method and an organosulphur precursor. The nanocomposite was characterized by XRD, SEM, and FTIR.
Neeta Gupta, A.L.S. Chandel, M. Mehta, Ashish Tiwari   +3 more
doaj   +1 more source

A semantic web service-based architecture for the interoperability of e-government services [PDF]

, 2005
We propose a semantically-enhanced architecture to address the issues of interoperability and service integration in e-government web information systems. An architecture for a life event portal based on Semantic Web Services (SWS) is described.
Cabral, L., Davies, R., Domingue, J., Gugliotta, A., Roberto, V., Rowlatt, M.   +5 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Freedom or Safety, the Dilemma of Technology-Based Surveillance Systems in the Context of E-Government

French Journal for Media Research, 2016
Cet article se propose de répondre aux questions suivantes : Les technologies de l'information renforcent-elles la position des citoyens face à l'État? La société obtient-elle une gouvernance plus démocratique en raison des applications du e-gouvernement?
AKGÜL Ali Erdem
doaj