Results 51 to 60 of about 22,560,687 (314)

Applicability of a Three-Layer Model for the Dynamic Analysis of Ballasted Railway Tracks

Vibration, 2021
In this paper, the three-layer model of ballasted railway track with discrete supports is analyzed to access its applicability. The model is referred as the discrete support model and abbreviated by DSM. For calibration, a 3D finite element (FE) model is
André F. S. Rodrigues, Zuzana Dimitrovová   +1 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The clinical trial activation process: a case study of an Italian public hospital

Trials
Background/aims In order to make the centers more attractive to trial sponsors, in recent years, some research institutions around the world have pursued projects to reorganize the pathway of trial activation, developing new organizational models to ...
Carolina Pelazza, Marta Betti, Francesca Marengo, Annalisa Roveta, Antonio Maconi   +4 more
doaj   +1 more source

Adherence to 2015 ESC Guidelines for the Treatment of Infective Endocarditis: A Retrospective Multicentre Study (LEIOT Study)

Antibiotics, 2023
Background: Infective endocarditis (IE) is still a severe disease with elevated morbidity and mortality. Nevertheless, the last European guidelines (GL) date back to 2015, and a recent survey described a diffuse suboptimal adherence to their ...
Carlo Pallotto, Cesare Bolla, Serena Penpa, Giovanni Genga, Cristina Sarda, Elisabetta Svizzeretto, Andrea Tommasi, Elisa Stolaj, Andrea Salvaderi, Giorgia Piceni, Antonio Maconi, Guido Chichino, Daniela Francisci, on behalf of the LEIOT Study Group   +13 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Assessing the long-term performance of cross-sectoral strategies for national infrastructure [PDF]

, 2014
National infrastructure systems (energy, transport, digital communications, water, and waste) provide essential services to society. Although for the most part these systems developed in a piecemeal way, they are now an integrated and highly ...
Velykiene, R., Thoung, C., Jim W Hall (16180139), Neha Rai (8962433), Jones, C., Preston, J.M., Street, R., Jim Watson (4460575), et al (16046813), Nicholls, R.J., Malleson, N., Hall, J.W., Leathard, A., Tyler, P., Powrie, W., Watson, G.V.R., Stringfellow, A., Birkin, M., Hickford, A.J., Baruah, P., Curtis, T.P., Kilsby, C.G., Henriques, J.J., Rai, N., Eyre, N., Lorenz, A., Chaudry, M., McLeod, F.   +27 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Research Agenda for the Semantic Grid: A Future e-Science Infrastructure

, 2001
e-Science offers a promising vision of how computer and communication technology can support and enhance the scientific process. It does this by enabling scientists to generate, analyse, share and discuss their insights, experiments and results in a more
De Roure, D., Jennings, N. R., Shadbolt, N. R., Jennings, NR, Roure, DD, Shadbolt, NR   +5 more
core   +1 more source

Electronic government in modern Russia: infrastructural problems and ways to solve them

Russian Journal of Economics and Law, 2020
Objective: to formulate the main problems in the field of organization and functioning of the infrastructure of the Russian e-government mechanism and to propose the possible ways to solve them.Methods: system-structural approach; dialectical method ...
A. A. Dvoretskiy
doaj   +1 more source

e-Infrastructures for Digital Libraries…the Future

, 2013
The digital ICT revolution is profoundly changing the way knowledge is created, communicated and is being deployed. New research methods based on computing and "big data" enable new means and forms for scientific collaboration also through policy measures supporting open access to data and research results.
Wim Jansen, Roberto Barbera, Michel Drescher, Antonella Fresa, Matthias L. Hemmje, Yannis E. Ioannidis, Norbert Meyer, Nick Poole, Peter Stanchev   +8 more
openaire   +2 more sources