Results 231 to 240 of about 21,399,637 (311)

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Recruiting children and young people with vision impairment for clinical research - experience from the SeeMyLife study. [PDF]

BMC Med Res Methodol
Gittel L, Finger RP, Richter V, Cadi A, Beck N, Colombo A, Gelžinis A, Gustafierro E, Incagli F, Kručaitė A, Lanza M, Leonardi M, Leroy BP, Nowakowska D, Nowomiejska K, Parmeggiani F, Pelletier V, Philippe A, Reffo ME, Slaghmuylder Y, Suppiej A, Laeng C, Žemaitienė R, Dollfus H, Terheyden JH, SeeMyLife consortium members.   +25 more
europepmc   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Belowground bud bank depletion constrains productivity recovery in long established perennial pastures despite nitrogen enrichment. [PDF]

Front Plant Sci
He K, He L, Dang H, Li J, Wang Q, Zhou Q, Wang J, Wei X.   +7 more
europepmc   +1 more source

The Role of Glucose Metabolism in <i>Xenopus</i> Primitive Myeloid Cell Development and Function. [PDF]

Int J Mol Sci
Demetriou L, Skourides PA, Christodoulou N.   +2 more
europepmc   +1 more source

Reconstitution of multistep recruitment of ULK1 to membranes in autophagy. [PDF]

Sci Adv
Duan Y, Lu Y, Paul S, Betz J, Wilhelm LP, Cook ASI, Ren X, Adriaenssens E, Martens S, Ganley IG, Hummer G, Hurley JH.   +11 more
europepmc   +1 more source

Systematic identification of p11 as a signaling modulator across the GPCRome. [PDF]

Sci Adv
Saarinen M, Kotliar IB, Höffkes I, Branzell N, Bowin CF, Dahl L, Da Silva E, Glaros V, Abney A, Bendes A, Kreslavsky T, Schwenk JM, Sakmar TP, Svenningsson P.   +13 more
europepmc   +1 more source

Fasting-induced hypoglycaemia in anaesthetised paediatric patients (FIGS): protocol of an opt-out approach to consent for a multicentre cohort study measuring glycaemia and ketonaemia. [PDF]

BJA Open
Lewis HF, Lemonde H, Gale C, Jones G, Logan K, Ayis S, Vincent A, MacCarrick T, Parnell J, Delgaty N, Wagster E, Favero S, Blaise BJ.   +12 more
europepmc   +1 more source