Results 211 to 220 of about 78,400 (265)

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri   +7 more
wiley   +1 more source

Codon-Optimized and de novo-Synthesized E-Selectin/AAV2 Dose-Response Study for Vascular Regeneration Gene Therapy. [PDF]

open access: yesAnn Surg
Voza FA   +15 more
europepmc   +1 more source

Prevention of In‐Stent Restenosis After PCI by Saponin Natural Products: Inhibition of Platelet Activation

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Percutaneous coronary intervention (PCI) enables coronary revascularisation and restores haemodynamic stability but also carries risks of delayed complications including in‐stent restenosis (ISR), a chronic progressive disease with endovascular damage after PCI, which compromises the long‐term efficacy of PCI.
Xueli Lei   +5 more
wiley   +1 more source

Tacrolimus versus hydrocortisone in management of atopic dermatitis in children, a randomized controlled double-blind study: New insights on TARC, CTACK, TSLP, and E-selectin. [PDF]

open access: yesImmun Inflamm Dis
Binsaleh AY   +12 more
europepmc   +1 more source

Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two‐sample Mendelian randomization

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 2, Page 267-279, February 2026.
A schematic representation of the two‐sample Mendelian randomization framework used to investigate the causal association between circulating leukocyte traits and diabetic retinopathy. ABSTRACT Aims/Introduction Leukocytes are implicated in the inflammatory cascades of diabetic retinopathy (DR), but their causal roles remain ambiguous.
Yan Wang   +7 more
wiley   +1 more source

GDF‐15 Levels in Cirrhosis Are Linked to Hepatic Fibrogenesis, Bacterial Translocation, and Worse Clinical Outcomes

open access: yesLiver International, Volume 46, Issue 2, February 2026.
ABSTRACT Background &Aims Growth differentiation factor‐15 (GDF‐15), a cell stress‐induced cytokine, is implicated in liver disease pathophysiology. We investigated GDF‐15 in cirrhosis, focusing on its association with disease‐driving pathomechanisms, platelet function, hepatic decompensation, and mortality.
Benedikt Silvester Hofer   +22 more
wiley   +1 more source

Grief‐Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model

open access: yesPsychophysiology, Volume 63, Issue 2, February 2026.
ABSTRACT Although the death of a loved one is a ubiquitous experience with chest pain a commonly reported symptom, grief‐related chest pain and particularly its physiological mechanisms remain under‐investigated. To address this gap, we adopted Rodger's approach to concept analysis to explore the psychoneuroimmunological mechanisms potentially linking ...
Sophia R. Evstigneev   +4 more
wiley   +1 more source

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