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Helvetica Chimica Acta, 2000
In the search for drugs that could control excessive leukocyte extravasation, we now report on modifications of the already known potent E-selectin antagonist 3 containing a cyclohexyllactic acid residue and a glucal-derived building block. Thus, we describe the synthesis and biological evaluation of a series of derivatives 6 with modified glucal ...
Rolf Bänteli +5 more
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In the search for drugs that could control excessive leukocyte extravasation, we now report on modifications of the already known potent E-selectin antagonist 3 containing a cyclohexyllactic acid residue and a glucal-derived building block. Thus, we describe the synthesis and biological evaluation of a series of derivatives 6 with modified glucal ...
Rolf Bänteli +5 more
openaire +1 more source
2007
P- and E-selectin, commonly referred to as the “endothelial” selectins, were initially described and characterized in the mid-late 1980s. P-selectin was first identified in 1984, using antibodies raised against activated platelets [1, 2]. In these initial publications, P-selectin was described as a protein of molecular weight of approximately 140 000 ...
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P- and E-selectin, commonly referred to as the “endothelial” selectins, were initially described and characterized in the mid-late 1980s. P-selectin was first identified in 1984, using antibodies raised against activated platelets [1, 2]. In these initial publications, P-selectin was described as a protein of molecular weight of approximately 140 000 ...
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CD44 enhances E-selectin-PSGL-1 interaction by binding to distinct sites on E-selectin
International Journal of Biological MacromoleculesPrecise roles of E-selectin in inflammatory cascades, particularly concerning its primary ligands PSGL-1 and CD44, remain incompletely understood. Existing observations such as their co-localization, shared E-selectin-triggered signaling pathways, and cooperative contributions to cellular adhesion hint at a potential interplay of the ligands.
Qihan, Ding +8 more
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E-Selectin, Internalization and Release
1993E-selectin also designated ELAM-1/LECAM2 (1) is a 115kD membrane glycoprotein (2) which is induced on human endothelial cells by TNF, IL-1 and bacterial LPS (2–5). E-selectin is engaged in the adherence of neutrophil granulocytes, a subpopulation of monocytes and T-cells (2,6–9).
W. A. Buurman +2 more
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Expression of E-selectin in the human kidney
Nephrology Dialysis Transplantation, 1993A A, Pall +7 more
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