Results 231 to 240 of about 21,662,479 (296)
Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.ABSTRACT Introduction Research on immune checkpoint molecules is increasing, reflecting their critical role in cancer pathogenesis. While PD‐1, PD‐L1, and CTLA‐4 have been widely studied in head and neck cancers, outcomes remain unsatisfactory, highlighting the need for novel prognostic markers and therapeutic targets.
Fırat Tevetoğlu +2 more
wiley +1 more source
Gastric Cancer: Pathobiology and Therapeutics
MedComm, Volume 7, Issue 6, June 2026.Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu +16 more
wiley +1 more source
Med Research, Volume 2, Issue 2, Page 236-279, June 2026.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Harnessing upregulated E-selectin while enhancing SDF-1α sensing redirects infused NK cells to the AML-perturbed bone marrow. [PDF]
LeukemiaSanz-Ortega L, Andersson A, Carlsten M.
europepmc +1 more source
Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities
MedComm – Oncology, Volume 5, Issue 2, June 2026.Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu +3 more
wiley +1 more source
Phytochemicals in Asthma Management: Mechanism, Translational Gap and Clinical Integration
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.The phytochemicals including flavonoids, alkaloids, terpenoids, and saponins modulate inflammatory, oxidative, and immune pathways in asthma. It highlights their mechanisms of action, translational challenges, advanced formulation strategies, and emerging clinical potential as adjunct therapies for precision‐based asthma management.
Pulak Majumder, Trisita Majumder
wiley +1 more source
Multimodal Assessment of Kidney Quality During 24‐h of Normothermic Machine Perfusion
Artificial Organs, Volume 50, Issue 6, Page 851-865, June 2026.Normothermic machine perfusion (NMP) has emerged as a promising tool for assessing kidney quality prior to transplantation; however, reliable biomarkers remain to be established. In this study, thirteen porcine kidneys were perfused for 24 h using an autologous leukocyte‐filtered whole blood‐based perfusate applying urine recirculation.
Marlene Pühringer +22 more
wiley +1 more source
T Cell Dysfunction in the Acidic Tumor Microenvironment
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Solid tumors are characterized by profound metabolic and vascular abnormalities that generate a hostile tumor microenvironment (TME) marked by extracellular acidosis, hypoxia, and nutrient deprivation. While the consequences of these conditions for cancer cell behavior have been extensively studied, their impact on anti‐tumor immune responses ...
F. B. Christiansen +4 more
wiley +1 more source
Psoriatic Neutrophils Are Primed in Circulation for Enhanced β<sub>2</sub>-Integrin-Dependent Recruitment and Effector Function on E-Selectin and ICAM-1. [PDF]
J Invest DermatolGarcia G +5 more
europepmc +1 more source