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Plenary Abstracts Session & Oral Presentations
HemaSphere, Volume 10, Issue S1, June 2026.
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Plasma Soluble E-Selectin in Necrotising Enterocolitis
European Journal of Pediatric Surgery, 2008 E-selectin is an important mediator of leukocyte-endothelial adhesion. It is expressed on activated endothelium, and shed into the circulation in its soluble form. In babies with necrotising enterocolitis (NEC), increased intestinal expression of E-selectin has been associated with multiple organ failure and an adverse outcome.
Khoo, A.K. +5 more
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Soluble E-Selectin in Arthritis
Clinical Immunology and Immunopathology, 1993Cellular adhesion molecules, such as E-selectin, function to recruit leukocytes into inflammatory lesions. Recently, a soluble form of this adhesion molecule, sE-selectin, has been described. In this study we determined soluble E-selectin (sE-selectin) in synovial fluid (SF) and blood samples from patients with rheumatoid arthritis (RA) and other ...
A E, Koch +3 more
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E-Selectin Binding Promotes Neutrophil Activationin Vivoin E-Selectin Transgenic Mice
Biochemical and Biophysical Research Communications, 1996E-selectin is a membrane protein expressed by endothelial cells activated by cytokines released during the inflammatory process; it plays an important role in neutrophil emigration into inflamed tissues. To further explore in vivo the function of E-selectin, we have generated transgenic mouse line expressing E-selectin under the control of a chicken ...
Araki, Masatake +6 more
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Conformation of the oligosaccharide receptor for E‐selectin
Biopolymers, 1994AbstractA tetrasaccharide related to the blood group oligosaccharides, known as sialyl LewisX, has been proposed as the receptor for the lectin responsible for leukocyte adhesion named alternatively as E‐selectin or ELAM‐1. The 13C‐ and 1H‐nmr spectra have been completely assigned for a tetrasaccharide model of this receptor, Neu5Ac α‐(2 → 3)‐Gal β‐(1 →
C, Mukhopadhyay, K E, Miller, C A, Bush
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Synthesis of a Potent Antagonist of E-Selectin
The Journal of Organic Chemistry, 2002A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a Rh(II)-catalyzed reaction. Stereocontrolled glycosylations rely on the anomeric activation of 2-pyridylthio carbonate as leaving group for the attachment of beta-D-
Stephen, Hanessian +2 more
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