Results 191 to 200 of about 211,577 (291)

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

E3 Ubiquitin-Protein Ligase RNF43 [PDF]

, 2020
openaire   +1 more source

Ubiquitin E3 ligase KPC1 governs mesenchymal metastatic melanoma reprogramming via proteasomal degradation of ZEB1. [PDF]

Cell Death Dis
Nakano Y, Bustos MA, Chong KK, Hayashi Y, Ciechanover A, Hoon DSB.   +5 more
europepmc   +1 more source

E3 Ubiquitin/ISG15 Ligase TRIM25 [PDF]

, 2020
openaire   +1 more source

RING-Type E3 Ligase OsRFPH2-6 Ubiquitinates Nuclear Factor Y Subunit OsNF-YA1 to Suppress Rice Immunity. [PDF]

Mol Plant Pathol
Bi Y, Tariq L, Wang H, Yan Y, Li D, Song F.   +5 more
europepmc   +1 more source

E3 Ubiquitin-Protein Ligase RING2 [PDF]

, 2020
openaire   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2. [PDF]

RSC Chem Biol
Kennedy CR, McPhie KA, Vuorinen A, Dudley-Fraser J, Esposito D, Maslen S, McCarthy WJ, Pettinger J, Skehel JM, Bush J, House D, Rittinger K.   +11 more
europepmc   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Author Correction: Identification of a non-inhibitory aptameric ligand to CRL2^ZYG11B E3 ligase for targeted protein degradation. [PDF]

Nat Commun
Yang Z, Chen M, Ge R, Zhou P, Pan W, Song J, Ma S, Chen S, Xu C, Zhou M, Mi W, Ni H, Chen H, Yao X, Dong X, Chen Y, Zhou J, Xuan C, Dong C, Yan H, Xie S.   +20 more
europepmc   +1 more source