Results 211 to 220 of about 135,650 (305)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1. [PDF]

Nat Commun
Andree GA, Stier LJ, Schmiederer K, Thielen AS, Schmid L, Maiwald SA, Gottemukkala KV, Du J, von Gronau S, Strasser C, Müller J, Henneberg LT, Guyot C, Kleiger G, Mann M, Murray PJ, Schulman BA.   +16 more
europepmc   +1 more source

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma. [PDF]

Biosci Rep
Zhang MP, Song Z, Zhang WS, Tan J, Zhao MH, Lian LJ, Cai J.   +6 more
europepmc   +1 more source

Developing a Chemical Approach to Study E3 Ligase Biology

The ubiquitin-proteasome system (UPS) is a highly regulated biological system in eukaryotic cells responsible for the correct disposal of proteins. E3 ubiquitin ligases are a family of proteins that catalyse the transfer of ubiquitin from an E2 ligase ...
Khan, Anam
core  

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS). [PDF]

Commun Biol
Tessier TM, Maitland MER, Kutera M, Dybas JM, St-Germain J, Arrowsmith CH, Barsyte-Lovejoy D, Zhang W, Raught B, Weitzman MD.   +9 more
europepmc   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1‐Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma

Exploration, EarlyView.
SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin, Zhidan Hua, Chen Liu, Minxia Yang, Beilei Zhang, Xiaofeng Zhu, Xiao Chen   +6 more
wiley   +1 more source

GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum. [PDF]

Nat Commun
Marapana DS, Lopaticki S, Balan B, Reaksudsan K, Cobbold SA, Geoghegan ND, Khurana S, Scally SW, Hickey P, Jayakrishnan N, Vaibhav V, Spall S, Yousef JM, Dagley LF, Goodman CD, Cozijnsen A, McFadden GI, Rogers KL, Jex A, Komander D, McCarthy JS, Tonkin CJ, Dixon MWA, Cowman AF.   +23 more
europepmc   +1 more source