Results 231 to 240 of about 135,650 (305)

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Loss of E3 ligase HvST1 function substantially increases distal crossover frequency. [PDF]

New Phytol
Orr JN, Mittmann SU, Ramsay L, Lewandowska D, Barakate A, Macaulay M, McCallum N, Waugh R, Colas I.   +8 more
europepmc   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12. [PDF]

Cell Rep
Ingersoll AJ, McCloud DM, Hu JY, Rape M.
europepmc   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37. [PDF]

Nat Struct Mol Biol
Yeow ZY, Sarju S, Chang FC, Xu LY, van Breugel M, Holland AJ.   +5 more
europepmc   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

The RING E3 ligase RLIM drives oxidative stress-induced stem cell dysfunction through MDM2-p53 signaling. [PDF]

J Biol Chem
Li X, Shen C, Li Y, Wu L, Gao J, Zhu D, Dong D, Chen F, Jin P.   +8 more
europepmc   +1 more source

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Disease mutation in gigaxonin-E3 ligase recapitulates giant axonal neuropathy in mice. [PDF]

Acta Neuropathol Commun
Liénard C, Pradeilles N, Cortier E, Hassen-Khodja C, Arias L, Ceprian-Costoso M, Picot A, Mausset-Bonnefont AL, Cazevieille C, Fiore F, Bomont P.   +10 more
europepmc   +1 more source