Results 251 to 260 of about 197,780 (305)

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

Cancer Science, EarlyView.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen, Xin Li, Weixiong Zhu, Yanxi Mu, Guoqing Zhang, Youheng Zhang, Yusheng Cheng, Wence Zhou   +7 more
wiley   +1 more source

Arabidopsis Ubiquitin E3 Ligase AtCHYR1 Promotes ROS Production in Plant Responses to Sugar Availability. [PDF]

Plants (Basel)
Ding S, Xue Y, Teng Y, Qin S, Wang H.
europepmc   +1 more source

Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor. [PDF]

Sci Adv
Wang Y, Liu M, Wang S, Mai X, Wang X, Teng F, Lyu T, Su MY, Stjepanovic G.   +8 more
europepmc   +1 more source

The E3 Ligase UBR5/Hyd Ensures Meiotic Fidelity Through Catalysis-Independent Regulation of β2-Tubulin in <i>Drosophila</i>. [PDF]

Genes (Basel)
Zhou L, Lin L, Zhang Y, Shen C, Qi Y, Lin X.   +5 more
europepmc   +1 more source

TaGW2-TaVOZ1 module regulates wheat salt tolerance via both E3 ligase-dependent and -independent pathways. [PDF]

Sci Adv
Li S, Zhang P, Wang X, Feng W, Zhu H, Qin Z, Chen B, Wang C, Nie X, Kang Z, Mao H.   +10 more
europepmc   +1 more source

Hijacking the MDM2 E3 Ligase with Novel BRD4-Targeting Proteolysis-Targeting Chimeras in Pancreatic Cancer Cells. [PDF]

Chembiochem
Ficu MP, Niculescu-Duvaz D, Aljarah M, Kershaw CS, Springer CJ.   +4 more
europepmc   +1 more source

Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking-Induced Lung Tumorigenesis. [PDF]

MedComm (2020)
Jeong IH, Yun JK, Jin JO, Lee GD, Lee PC.   +4 more
europepmc   +1 more source

Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4

Spiteri VA, Segal D, Correa-Saez A, Iso K, Casement R, Munoz i Ordono M, Nakasone MA, Sathe G, Schatz C, Peters HE, Doward M, Kainacher L, Cowan AD, Ciulli A, Winter GE.   +14 more
europepmc   +1 more source

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E3 ubiquitin ligases

Essays in Biochemistry, 2005
The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds).
Helen C, Ardley, Philip A, Robinson
openaire   +2 more sources