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HECT-Type E3 Ubiquitin Ligases in Cancer
Trends in Biochemical Sciences, 2019Ubiquitination, a post-translational modification that involves a covalent attachment of ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end of a three-enzyme cascade, E3 ubiquitin ligases (E3s) recruit substrates and promote or directly catalyze ubiquitin transfer to targets.
Francesca Bernassola +2 more
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Notch Interacts with an E3 Ligase
Science Signaling, 2001The membrane protein Notch transduces signals from the cell surface to the transcription machinery by deploying its cleaved intracellular (IC) domain to the nucleus. It is less clear how Notch action is turned off once its mission is fulfilled in the nucleus.
openaire +2 more sources
Inhibitors for E3 ubiquitin ligases
Nature Biotechnology, 2010Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.
John R Lydeard, J Wade Harper
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Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis
Annual Review of Biochemistry, 2021Brenda Schulman
exaly
Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cell, 2023Brenda Schulman +2 more
exaly
An engineered platform for reconstituting functional multisubunit SCF E3 ligase in vitro
Molecular Plant, 2022Mingjiang Chen
exaly