Results 271 to 280 of about 135,650 (305)
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Inhibitors for E3 ubiquitin ligases
Nature Biotechnology, 2010Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.
John R Lydeard, J Wade Harper
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E3 ubiquitin ligase that recognizes sugar chains
Nature, 2002N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-linked high-mannose oligosaccharides
Yukiko, Yoshida +10 more
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Notch Interacts with an E3 Ligase
Science Signaling, 2001The membrane protein Notch transduces signals from the cell surface to the transcription machinery by deploying its cleaved intracellular (IC) domain to the nucleus. It is less clear how Notch action is turned off once its mission is fulfilled in the nucleus.
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Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cell, 2023Kheewoong Baek +2 more
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An engineered platform for reconstituting functional multisubunit SCF E3 ligase in vitro
Molecular Plant, 2022Simiao Liu, Mingsheng Chen
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Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy
Journal of Cell Biology, 2022Jun Zheng, Guisheng Zhong, Min Zhuang
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