Results 241 to 250 of about 194,539 (300)

Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction-associated steatohepatitis. [PDF]

Cell Commun Signal
Chen XX, Shi HT, Xiao LL, Li H, Du BB, Huang Z, Zhang DH, Wu LM, Wu LN, Zhang JL.   +9 more
europepmc   +1 more source

ALDH2 inhibits FASN stabilization via the E3 ligase CBL to suppress lipid accumulation and liver cancer development. [PDF]

Biol Direct
Wang Y, Li L, Qu F, Hua T, Chen C, Yang L, Jiang R, Liu X, Cheng P, Min H, Wang Y, Pan X, Sun D, Tang R, Liu R, You H, Kong F.   +16 more
europepmc   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule-associated protein tau. [PDF]

FEBS J
Aoki S, Onodera W, Takashima A, Kawasaki K, Imadegawa K, Kurahashi H, Oishi M, Asahi T, Soeda Y.   +8 more
europepmc   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

E3 ligase LMO7 enhances temozolomide sensitivity by promoting MGMT degradation in lung cancer. [PDF]

J Biol Chem
Li J, Feng X, Deng Y, Chen B, Miao L, Liu Z, Sun Z, Hu L, Ma J, Zeng L, Wang X, Zhao Y.   +11 more
europepmc   +1 more source

Comparative Analysis of Salmonella typhimurium‐Induced Transcriptomic Changes in the Spleen of Beijing‐You Chickens and Guang Ming Broilers

Animal Research and One Health, EarlyView.
This study analyzed the spleen transcriptomes of different chicken breeds, identified key differentially expressed genes (EGR1, FOS, and DUSP1) that regulate resistance to Salmonella infection, and elucidated the underlying regulatory mechanisms, thereby providing new targets for disease‐resistant breeding in poultry.
Zixuan Wang, Man Deng, He Geng, Jumei Zheng, Xiang Li, Yaping Wang, Qinghe Li, Guiping Zhao, Qiao Wang   +8 more
wiley   +1 more source

Potato StRWA2 recruits the E3 ligase StSNIPER2 to destabilize NLRs and promote <i>Phytophthora infestans</i> infection. [PDF]

Hortic Res
Chen Z, He Z, Du J, Li Y, Niu S, Ma A, Chen Q, Guo H, Fan J, Ren M, Xu G, Dou D, Yang J, Jing M, Wang X.   +14 more
europepmc   +1 more source

Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma. [PDF]

Biosci Rep
Zhang MP, Song Z, Zhang WS, Tan J, Zhao MH, Lian LJ, Cai J.   +6 more
europepmc   +1 more source

Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1. [PDF]

Nat Commun
Andree GA, Stier LJ, Schmiederer K, Thielen AS, Schmid L, Maiwald SA, Gottemukkala KV, Du J, von Gronau S, Strasser C, Müller J, Henneberg LT, Guyot C, Kleiger G, Mann M, Murray PJ, Schulman BA.   +16 more
europepmc   +1 more source