Results 181 to 190 of about 86,081 (238)

Oncolytic virus-mediated remodeling of tumor microenvironment enhances efficacy of an HPV16 E6/E7 mRNA vaccine in an HPV-positive tumor. [PDF]

Mol Ther Oncol
Johnson K, Wu W, Lim JJ, Tu N, Zhang SX.
europepmc   +1 more source

Post‐Hoc Long‐Read Sequencing Links Leukemic Mutation Status to Single‐Cell Transcriptomes

European Journal of Haematology, EarlyView.
ABSTRACT Single‐cell RNA‐sequencing‐based characterization of cells that belong to the neoplastic clone is a major challenge in hematologic neoplasms, where malignant and normal cells coexist. Confident molecular profiling requires simultaneous analysis of gene expression and genetic mutations in individual cells, an ability that is not supported by ...
Sofia Papavasileiou, Chenyan Wu, Daryl Boey, Lucille Margerie, Jiezhen Mo, Ulla Olsson‐Strömberg, Stina Söderlund, Gunnar Nilsson, Joakim S. Dahlin   +8 more
wiley   +1 more source

An Outer Membrane Vesicle-Based Vaccine Combined with alb-Flt3L Promotes Durable Antitumor Immunity in HPV-Associated Cancer. [PDF]

Vaccines (Basel)
Liu Y, Xu Y, Chang YC, Tsai YC, Wu TC, Hung CF.   +5 more
europepmc   +1 more source

Computed tomographic arthrography of the coxofemoral joint in horses

Equine Veterinary Education, EarlyView.
Summary Background Investigation of pathology relating to the coxofemoral joint (CFJ) in horses includes intra‐articular analgesia and diagnostic imaging using ultrasonography, radiography, scintigraphy and computed tomography (CT). While CT arthrography has been described for diagnosing intra‐articular ligament and cartilage injuries in different ...
S. J. Attin, M. Kristoffersen, S. Aarsvold   +2 more
wiley   +1 more source

Multidrug-resistant and virulence traits in genetically distinct vesicular Leptospira inhabiting farmland and sewage in Southern India. [PDF]

Sci Rep
Sonam A, Hameed A, Stothard P, Grant JR, Tellis RC, Arun AB.   +5 more
europepmc   +1 more source

Fatigue of AM TiAl6V4: Probabilistic Modelling of the Size Influence as a Transfer Method From Test Specimen to Part

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT This paper investigates the fatigue behavior of additively manufactured TiAl6V4 by comparing two specimen geometries with different highly stressed volumes. A fracture mechanical approach based on the El‐Haddad–Smith–Topper model is combined with defect analysis through X‐ray computed tomography.
Sebastian Mansky, Dirk Herzog, Ingomar Kelbassa   +2 more
wiley   +1 more source

Preventive and therapeutic efficacy of mRNA/LNP vaccines encoding HPV16 E6 and E7 in an early-intervention HPV tumor mouse models. [PDF]

Hum Vaccin Immunother
Saithong S, Prompetchara E, Ketloy C, Khawsang C, Tharakhet K, Kaewpang P, Yostrerat N, Wangsoontorn P, Charsangbong K, Lam K, Heyes J, Weissman D, Ruxrungtham K.   +12 more
europepmc   +1 more source

Hippo pathway disruption and YAP1 activation in anogenital papillary squamous intraepithelial lesion

Histopathology, EarlyView.
Disruption of the Hippo Pathway with YAP1 activation is a consistent finding in papillary squamous intraepithelial lesions and may underlie their altered epithelial maturation and HPV E6/E7 expression patterns, providing new insight into the pathogenesis of this distinct low‐risk HPV‐associated lesion.
Gloria Zhang, Karen L. Talia, W. Glenn McCluggage, Robert A. Soslow, Bin Yang   +4 more
wiley   +1 more source

Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 <i>E5</i>, <i>E6</i>, and <i>E7</i> oncogene expression in breast cancer. [PDF]

Explor Target Antitumor Ther
de Oliveira Isídio BE, Fontes PHB, da Silva GRP, Leão SL, de França São Marcos B, Simões IS, Barros EFG, Lussón DB, de Araujo GV, de Farias ID, de Melo KMTB, de Queiroz NL, da Silva SMS, Santos VEP, de Freitas AC.   +14 more
europepmc   +1 more source

Dynamic Trust Formation in AI‐Enabled Automation: A Longitudinal Case Study of an Advanced Driver Assistance System

Information Systems Journal, EarlyView.
ABSTRACT Artificial intelligence (AI)–enabled automation is often utilised in systems that perform human tasks. While useful, these technologies pose a risk of adverse consequences in the case of AI failures as they operate in open environments, learn and are subject to continuous updates.
Kari M. Koskinen, Niina Mallat, Virpi Kristiina Tuunainen, Antti Lyyra   +3 more
wiley   +1 more source